Breast cancer is a condition characterized by the uncontrolled division of breast cells. While various factors contribute to breast cancer, genetics plays a significant role. Approximately 5-10% of breast cancer cases have a genetic basis, meaning they result from specific genetic mutations.
Genetics, in this context, pertains to the study of genes. Genes are fundamental units of DNA (Deoxyribose Nucleic Acid), which exists in every cell of our body. DNA contains instructions that guide cell development and function, essentially controlling all cellular activities.
In addition to genetics, several factors can contribute to breast cancer risk, including obesity, age, and personal and family history. However, some causes, such as genetic factors, are beyond our control.
Mutation refers to changes in the genetic code of DNA. When a specific gene mutates, it disrupts its normal function, leading to abnormal cell activities. These genetic changes can be passed down to other family members.
Two crucial genes associated with breast cancer are BRCA1 and BRCA2. Normally, these genes repair damaged DNA, preventing uncontrolled cell division. Mutations in these genes, often referred to as tumor suppressor genes, can lead to uncontrolled cell growth, a hallmark of cancer.
While BRCA1 and BRCA2 mutations are well-known, other genes can increase the risk of breast cancer, although less commonly. These genes include ATM, PALB2, TP53, CHEK2, and PTEN. They typically regulate cell growth, but any mutation in these genes can result in uncontrolled cell division, contributing to breast cancer development.
If you have any uncertainties or seek a better understanding of breast cancer, we invite you to reach out to CION Cancer Clinics. Our team is here to assist you. Feel free to contact us at 1800 120 2676, or you can conveniently fill out the form through the provided link.