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Biomarker Testing & Eligibility

Where to Get Biomarker Testing Done in Hyderabad

Holding a biomarker order from your oncologist and unsure who actually runs the test? PD-L1, MSI and TMB testing for CION patients is coordinated through NABL/CAP-accredited partner pathology and molecular-diagnostics laboratories in Hyderabad — not a single walk-in counter — with your sample tracked from an existing biopsy block through to a written report. This page explains which labs are typically involved, how the sample travels, and what turnaround and cost to expect; it explains the pathway only and does not interpret any individual patient's result.

Medically reviewed by Dr. C. Raghavendra Reddy, Medical Oncologist, MBBS (Gold Medal) · DNB · DM (Medical Oncology, Gold Medal) · Last reviewed August 2026

  • Lab-coordinated, not walk-in — CION refers PD-L1/MSI/TMB testing to accredited partner labs matched to the specific test your case needs
  • Usually your existing sample — testing is normally run on tissue already collected during a prior biopsy or surgery, not a fresh procedure
  • 3-10 working days, typically — an IHC stain like PD-L1 is faster than a multi-gene NGS panel; costs are indicative, confirmed before sampling
  • One piece of a bigger picture — your tumour board reads the result alongside cancer type and stage, never as a standalone verdict
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Where can PD-L1 or biomarker testing actually be done in Hyderabad?

Biomarker testing is not performed at a single hospital counter — it is coordinated through accredited partner pathology and molecular-diagnostics laboratories, chosen for the specific test your case needs. A PD-L1 immunohistochemistry (IHC) stain and a broader MSI/TMB next-generation-sequencing (NGS) panel are often run at different specialised labs, sometimes in different parts of the city, because the two techniques use different equipment and expertise.

Your oncology team places the referral, tracks the sample through the lab, and receives the signed report — you don't have to independently identify or approach the lab yourself. This coordination model is deliberate: it lets each test go to whichever accredited facility is genuinely equipped to run it well, rather than routing everything through one in-house counter that may not carry every assay.

Biomarker testing for CION patients is coordinated at accredited partner laboratories, not run in-house. This page explains the pathway and terminology in general terms; it does not interpret your specific report or promise a particular treatment outcome.

Did you know?

The two main report formats you'll see for immunotherapy biomarkers are IHC-based scores (like PD-L1 TPS/CPS, read under a microscope) and NGS-panel results (like MSI or TMB, read from a sequencing machine) — they use completely different scales, so a "high" or "low" only makes sense against the specific test it came from.

What Gets Tested

Common biomarker tests and their result bands

Check your report's methodology line to see which of these your sample was tested for, and by which method.

Biomarker Test method Typical result bands What it's used for
PD-L1 IHC (TPS or CPS score) <1% negative · 1-49% low-positive · ≥50% high-positive (thresholds vary by cancer type) Lung, gastric, cervical, head & neck cancers, among others
MSI PCR or IHC, confirmed by NGS MSI-High vs. microsatellite-stable (MSS) Colorectal, endometrial and other solid tumours
TMB NGS multi-gene panel Commonly cited cut-off: ≥10 mutations/Mb "high" vs. below "low" Tumour-agnostic eligibility review across cancer types

Result bands shown are the commonly cited reference ranges used in NCCN/ASCO patient-education materials, indicative as of August 2026. Your oncologist interprets your specific report against your cancer type and the treatment being considered — this table is general education, not an eligibility statement.

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Dr. Naresh Gundu
Medical Oncologist

Dr. Naresh Gundu

MBBS, DNB (Internal Medicine), DM (Medical Oncology)

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Dr. C. Raghavendra Reddy
Medical Oncologist

Dr. C. Raghavendra Reddy

MBBS(Gold Medal), DNB(General Medicine), DM(Medical Oncology)(Gold Medal)

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Dr. Bharati Devi Gorantla
Medical Oncologist

Dr. Bharati Devi Gorantla

MBBS, MD(General Medicine), DM(Medical Oncology)(Adyar,Chennai), ECMO, MRCP SCE(UK)

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Dr. Owais Mohammed
Medical Oncologist

Dr. Owais Mohammed

MBBS, MD (General Medicine), DrNB (Medical Oncology), ECMO, MRCP SCE (Medical Oncology) (UK)

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Dr. T. Raghavender Reddy
Medical Oncologist

Dr. T. Raghavender Reddy

MBBS, DM (Medical Oncology), MD (Radiation Oncology)

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Dr. N. Kiranmayee
Medical Oncologist

Dr. N. Kiranmayee

MBBS, DM (Medical Oncology), MD (Internal Medicine)

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Dr. Muralidhar Muddusetty
Surgical Oncologist

Dr. Muralidhar Muddusetty

MBBS (AIIMS), MS (Surgery) (AIIMS), DNB (Surgical Oncology), MRCS (Edinburgh)

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Dr. Raghavendra Naik
Surgical Oncologist

Dr. Raghavendra Naik

MBBS, MS (General Surgery), M.Ch (Surgical Oncology)

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Dr. Mohammed  Imaduddin
Surgical Oncologist

Dr. Mohammed Imaduddin

M.B.B.S, MS (General Surgery), M.Ch (Surgical Oncology)

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Dr. Vinay Mamidala
Surgical Oncologist

Dr. Vinay Mamidala

MBBS, MS(General Surgery), M.Ch(Surgical Oncology), FMAS, FARIS(Ongoing)

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Dr. Paila Gowri Naidu
Surgical Oncologist

Dr. Paila Gowri Naidu

MBBS, MS (General Surgery), M.Ch (Surgical Oncology), FMAS

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Dr. Venkata Sushma P
Radiation Oncologist

Dr. Venkata Sushma P

MBBS, MD (Radiation Oncology)

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Dr. Kirti Ranjan Mohanty
Radiation Oncologist

Dr. Kirti Ranjan Mohanty

MBBS, MD (Radiation Oncology)

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Dr. Gangadhar Vajrala
Radiation Oncologist

Dr. Gangadhar Vajrala

MBBS, MD (Radiation Oncology), MPH

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Dr. Basudev Pokhrel
Hematologist

Dr. Basudev Pokhrel

MBBS, M.D (Immunohematology & Blood Transfusion)

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Dr. Mohammed Imran
Interventional Radiologist

Dr. Mohammed Imran

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Dr. Vajja Sandeep Kumar
Surgical Oncologist

Dr. Vajja Sandeep Kumar

MBBS, MS (General Surgery), DrNB (Surgical Oncology), FALS Oncology

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Dr. Sridhar Kamani
Surgical Oncologist

Dr. Sridhar Kamani

MBBS, MS (General Surgery), DrNB (Surgical Oncology)

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The Sample Pathway

What is the sample pathway from biopsy to biomarker report?

Five steps carry a tissue sample from an existing biopsy to a signed report your oncologist can discuss with you.

  1. Tissue is identified from an existing sample

    Most biomarker tests use the tissue block already collected during a prior biopsy or surgery — a fresh procedure is usually needed only if that sample is too old, too small, or poorly preserved.

  2. Sample is sent to an accredited partner lab

    Your oncology team routes the request to the specific NABL/CAP-accredited lab equipped for that test — PD-L1 IHC and NGS panels are often processed at different specialised facilities.

  3. Staining or sequencing is performed

    The lab stains the sample (for an IHC test like PD-L1) or sequences it (for MSI, TMB or a multi-gene panel), following the manufacturer-validated protocol for that assay.

  4. A pathologist reviews and signs off the report

    Results are scored and reviewed by a qualified pathologist before the report is finalised — this is why turnaround takes days, not hours, even once the lab work itself is done.

  5. Your oncology team discusses the report with you

    The signed report goes to your treating oncologist, who explains what it means for your options at a consultation — not as a number read out on its own.

Already have a biomarker order to act on?

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Turnaround & Cost

How long does it take, and what does it cost?

Figures below are indicative, as of August 2026 — the exact turnaround and price depend on the lab and the specific panel ordered, and should always be confirmed in writing before sampling.

Test type Typical turnaround Indicative cost*
Single-marker IHC (e.g. PD-L1) 3-5 working days ≈ ₹8,000-₹15,000
MSI (PCR/IHC) 4-7 working days ≈ ₹6,000-₹12,000
Multi-gene NGS panel (incl. TMB) 7-10 working days or longer ≈ ₹25,000-₹45,000+

*Indicative, as of August 2026. Actual cost and turnaround vary by lab, sample quality and the exact panel ordered — confirm both in writing before your sample is sent. Aarogyasri/scheme coverage for specific panels should be checked directly with the scheme and the lab.

Before You Send A Sample

What's worth checking before biomarker testing begins

  • Lab accreditation — confirm the lab carries NABL accreditation, and CAP accreditation for specialised molecular panels.
  • Right assay for the drug being considered — a PD-L1 clone validated for one drug isn't automatically valid for another; ask which clone or panel your case needs.
  • Enough tissue on the block — very small or old samples can fail to give a usable result; ask upfront whether the existing sample is sufficient.
  • Written cost and turnaround estimate — get this in writing before the sample is sent, since costs are indicative and vary by lab and panel.
  • Who explains the result — confirm your oncology team, not the lab report alone, will walk you through what the result means for your options.
Related Reading

Understanding the wider biomarker picture

This page explains general biomarker-testing terminology and the sample pathway for education only, and does not interpret any individual patient's report or guarantee eligibility for any treatment. Testing is coordinated at accredited partner laboratories; bring your report to a consultation for a doctor's assessment of what it means for you.

You're not alone

Thousands of families have navigated this exact referral

A biomarker order can feel like one more confusing step. Our oncologists take the time to explain, in plain language, where testing happens, how long it takes, and what the result means for your options.

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Successful Chemo & Radiation Done by Dr. Owais Mohammed & Dr. Kirti Ranjan Mohanty

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Common questions

Biomarker testing in Hyderabad: your questions answered

Which labs in Hyderabad offer PD-L1 or biomarker testing?
Biomarker testing for CION patients is not run at a single walk-in counter — it is coordinated through accredited partner pathology and molecular-diagnostics laboratories in Hyderabad that hold NABL and, for many panels, CAP accreditation. Your oncology team identifies which lab is appropriate for the specific test your case needs — a PD-L1 immunohistochemistry (IHC) stain and an MSI/TMB next-generation-sequencing (NGS) panel are often processed at different specialised labs, even for the same patient.
What is the sample pathway — from biopsy to biomarker report?
The tissue used for biomarker testing is almost always collected during a biopsy or surgery you have already had — testing rarely requires a fresh procedure on its own. The stored tissue block is sent to the accredited lab, where it is stained (for PD-L1) or sequenced (for MSI, TMB and multi-gene panels), reviewed and signed off by a pathologist, and the written report is returned to your oncology team, who then discuss the result with you at a consultation.
How long does biomarker testing take, and what does it cost?
A single-marker IHC test such as PD-L1 typically takes about 3-5 working days once the lab receives an adequate sample, while a multi-gene NGS panel covering MSI, TMB and other markers usually takes 7-10 working days or longer. Indicative cost, as of August 2026, runs roughly ₹8,000-₹15,000 for a single IHC marker and ₹25,000-₹45,000 or more for a broader NGS panel — exact pricing depends on the specific test and lab, and should always be confirmed in writing before sampling.
Can CION interpret my biomarker report for me?
This page explains biomarker terminology and the general testing pathway; it does not interpret any individual patient's report. Bring your report to a free consultation and a CION oncologist will review it as part of your full clinical picture — cancer type, stage and other test results together — rather than reading the biomarker number in isolation.
Does a "high" biomarker score mean immunotherapy is guaranteed to work?
No single biomarker score is a guarantee either way. A high PD-L1, MSI-High or high-TMB result makes a patient more likely to be considered for immunotherapy and is associated with response rates in a proportion of patients in published trials, but it does not promise a particular outcome for any one person. Your oncology team weighs the biomarker result alongside cancer type, stage, overall health and other findings before recommending a treatment plan.
Do I need a fresh biopsy, or can an older tissue sample be used?
Many labs can test a tissue block from a biopsy or surgery done some time ago, provided the sample is well preserved and there is enough tissue left. Very old, very small, or poorly preserved samples sometimes fail to give a usable result, and biomarker expression can genuinely change over time or after treatment — in either situation your oncologist may recommend a fresh sample. This is a lab and clinical judgement made case by case, not a fixed rule this page can state in advance.
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