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Reading your PET report

Why Your Report Mentions — the Liver and Blood Pool

The liver and blood pool appear in your PET report as measuring references, not findings. Radiologists compare the uptake in any suspicious area against these two fixed points to produce a score. Nothing about their appearance in the report means something is wrong with those organs.

Medically reviewed by Dr. Bharati Devi Gorantla, Medical Oncologist, MBBS · MD · DM (Adyar, Chennai) · ECMO · MRCP SCE (UK) · Last reviewed September 2026

  • Not a finding about your liver — Your liver is listed as a measuring reference, not as an area of concern in your scan.
  • Two fixed yardsticks — Every Deauville score compares uptake against the mediastinal blood pool and the liver.
  • Required by international guidance — EANM and LYRIC require these same two reference points at every PET centre worldwide.
  • Your doctor reads the number — The references produce a score. What that score means for your care is a clinical judgement.
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Your PET scan report mentions the liver and blood pool because they are internal reference standards — not because anything is wrong with them. Radiologists compare uptake in any area of concern against these two fixed points to produce a score. This is the basis of Deauville scoring, used in lymphoma and some other cancers to measure treatment response.

How do the liver and blood pool differ as reference points?

FeatureMediastinal blood poolLiver
What it isTracer activity in the large blood vessels near the heartAn organ that absorbs the tracer at a stable, predictable level in most people
Position in Deauville scaleLower reference — score 2 is uptake at or below this levelUpper reference — score 4 is moderately above this, score 5 is markedly above
What 'at this level' meansLow uptake, close to background — generally a favourable signModerate uptake — the area sits between the two references, scored as 3
What 'above this level' meansMild increase from background — may reach score 3Clearly elevated uptake — score 4 or 5 on the Deauville scale

What does 'above the liver' mean in a report?

When your report says uptake is above the liver, it means the area being scored is absorbing more tracer than your liver does. On the Deauville scale, this places the score at 4 or 5.

A score of 4 means the uptake is moderately above liver level. A score of 5 means it is markedly higher, or that new areas of uptake have appeared. Your oncologist uses the score alongside other clinical information — not as a standalone verdict.

The same score can mean different things depending on your cancer type, where you are in treatment, and what your previous scans showed. Only your doctor can tell you what the number means for you.

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What do these terms in your report mean?

FDG (tracer)
A radioactive glucose injected before the scan. More active cells absorb more of it, which is why cancer and inflammation often appear as bright areas.
Uptake
How much tracer an area absorbs. Higher uptake appears brighter on the scan image and is measured against the two reference points.
Mediastinal blood pool
The lower reference point — tracer activity in the large vessels near the heart. Uptake at or below this level scores 1 or 2 on the Deauville scale.
Deauville score
A 1-to-5 scale comparing uptake in a lesion against the blood pool and the liver. Widely used in lymphoma response assessment and in some other cancers.
Background activity
The baseline level of tracer in normal, less metabolically active tissue. The mediastinal blood pool is one standard measure of this baseline.

What questions should you bring to your appointment?

  • Ask which Deauville score the report gives and what it means at this stage of your treatment.
  • Ask whether the score has changed since your last scan.
  • Ask what the next step is based on this result.
  • Tell your team if your blood sugar was high or you were not fasting before the scan — this affects how the liver takes up the tracer.
  • Bring a printed or saved copy of your report so your team can discuss the exact wording with you.

Did you know?

The Deauville scoring system was built around one principle: the same measurement should mean the same thing at every centre in the world.

Anchoring each score to the liver and blood pool — organs present in every patient — is what makes that consistency possible across thousands of PET centres.

Source: LYRIC criteria and EANM procedure guidelines for tumour FDG-PET/CT imaging

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Common questions

Frequently asked questions

Why does my report mention the liver if my cancer is not in the liver?

The liver appears as a measuring reference, not as a finding. Radiologists need a predictable, stable level of tracer activity to compare against suspicious areas, and the liver provides that reliably. If the radiologist had found a concern in your liver, it would appear differently — described as a lesion or an area of abnormal uptake with its own measurements. Seeing the liver named as a reference point is routine and not a cause for concern.

Does a higher Deauville score always mean worse?

Not necessarily. The score reflects how much tracer an area absorbs relative to the two reference points. Whether that is concerning depends on your cancer type, where you are in treatment, and what your previous scans showed. A score of 4 early in treatment may prompt a different response than the same score after the final cycle. Your oncologist interprets the number in context — it is not a verdict on its own.

What does a Deauville score of 3 mean?

A score of 3 means uptake is above the mediastinal blood pool but at or below liver level. In some cancers and scoring systems this is considered a partial response; in others it may be interpreted differently. The significance of a 3 is not something to work out from the report alone — it is a direct question for your oncologist, who will read it against your full clinical picture.

Does diabetes or high blood sugar affect these readings?

Yes. Elevated blood sugar changes how the tracer distributes in the body, including how much the liver takes up. This is why most PET centres ask you to fast before the scan. If your blood sugar was elevated on the day, the reporting radiologist will usually note it. Tell your oncologist so they can factor it into the interpretation of your result.

Is the mediastinal blood pool the same as blood vessels throughout the body?

No. The mediastinal blood pool refers specifically to tracer activity measured in the large blood vessels running through the chest — most often the descending aorta or the heart chambers. Radiologists use this location because it gives a consistent, reproducible baseline that is unlikely to be affected by disease at common cancer sites. It is not a reading from blood vessels throughout the body.

Can I have a PET scan if I have a liver condition?

This is a question for the team arranging your scan. Liver conditions can affect how much tracer the liver takes up, which may influence how useful it is as a reference point. Your oncologist and the nuclear medicine team will assess this before the scan is scheduled. Do not assume you cannot have one — raise it with your team so they can plan accordingly.

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