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Childhood Cancer Types — Parent’s Guide

Childhood brain tumours — overview & types explained

Medically reviewed by Dr. C. Raghavendra Reddy, DM (Medical Oncology, Gold Medal) · Last reviewed June 2026

If your child has been told they have a brain tumour — or you are searching because something does not feel right — you deserve a clear, honest answer. A brain tumour in children is an abnormal growth of cells inside or around the brain. It is the second most common cancer in children overall, and it covers many different tumour types, each with a different location, behaviour, and treatment path. This page explains what that means in plain language.

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Understanding the diagnosis

What is a brain tumour in a child?

A brain tumour is an abnormal collection of cells growing inside the brain or the spinal cord. In children, these tumours most often grow within the brain itself — in the cerebellum (the area controlling balance and coordination at the back of the skull), the brainstem (the connection between brain and spinal cord), or the cerebral hemispheres (the large thinking and moving regions). Some tumours arise from supporting brain cells called glial cells; others arise from the cells that line the brain’s fluid-filled spaces (ependymal cells) or from the developing cells of the nervous system.

Unlike most cancers, a childhood brain tumour does not begin somewhere else in the body and spread to the brain. It arises in place — which is why the tumour’s exact location matters enormously. A tumour pressing on the cerebellum will cause balance and coordination problems. One pressing near the optic pathway will affect vision. One in or near the brainstem will affect swallowing, eye movements, or facial sensation. Understanding the location helps the specialist team plan surgery, radiation, and supportive care in a way that protects the functions most important to the child.

Childhood brain tumours are not caused by anything the family did. In the vast majority of cases, no preventable cause or genetic inheritance is identified. A very small number of children who have certain rare inherited conditions (such as neurofibromatosis type 1 or Li-Fraumeni syndrome) carry a higher risk, but most children who develop a brain tumour have no such background. This distinction is important: you are not to blame.

Finally, the term “brain tumour” covers many different diseases. A low-grade pilocytic astrocytoma and a high-grade diffuse intrinsic pontine glioma are both called brain tumours — but they behave completely differently and need very different approaches. This is why the precise diagnosis, including molecular testing, matters so much before any treatment is chosen. Explore the types below, and see How Childhood Cancer Is Diagnosed for a detailed guide to the diagnostic process.

Did you know?

Brain and central nervous system tumours are the most common solid tumour group in children, accounting for roughly 15–20% of all childhood cancers. They are also the leading cause of cancer-related death in children under 15 — which underscores how important early recognition and specialist management are. Diagnosis has become more precise in recent years because the WHO 2021 classification now integrates molecular and genetic tumour characteristics alongside the microscopic appearance — helping teams select the most appropriate treatment for each specific tumour.

Source: WHO Classification of CNS Tumours 2021 · ICMR National Cancer Registry Programme
Paediatric brain tumour types

Types of brain tumours in children

Each childhood brain tumour is a different disease. Location, cell type, grade, and molecular markers all determine the right treatment path. Here are the main types a parent needs to know about.

Most common group

Low-grade glioma (including pilocytic astrocytoma)

These are slow-growing tumours that arise from the brain’s support cells (glial cells). Pilocytic astrocytoma (WHO grade 1) is the single most common brain tumour in children and frequently occurs in the cerebellum. Because they grow slowly and are well-defined, they are often very amenable to surgical removal.

  • Often curable with surgery alone if completely removed
  • Rarely spreads to other parts of the brain or spine
  • Molecular marker BRAF fusion is commonly found and guides treatment
Most common malignant

Medulloblastoma

Medulloblastoma is the most common malignant brain tumour in children. It arises in the cerebellum (the back of the brain) and can spread through the cerebrospinal fluid to the spine. It is a fast-growing tumour but it responds well to treatment in many cases, particularly in older children with standard-risk features.

  • Four molecular subgroups (WNT, SHH, Group 3, Group 4) guide treatment intensity
  • Treatment typically involves surgery followed by radiation and chemotherapy
  • WNT subgroup generally has the most favourable outcomes
Lining of fluid spaces

Ependymoma

Ependymomas grow from the ependymal cells that line the ventricles (fluid-filled spaces) inside the brain and the central canal of the spinal cord. In children they most often arise in the posterior fossa (back of the brain near the brainstem). Surgery is the key treatment, and the extent of tumour removal is the single most important prognostic factor.

  • Complete surgical removal is the primary goal
  • Radiation is usually used after surgery in children over 1–3 years
  • Molecular subtype (RELA fusion vs. YAP1 fusion) shapes treatment decisions
Brainstem

Diffuse midline glioma (DIPG / DMG)

Diffuse intrinsic pontine glioma (now classified as diffuse midline glioma, H3 K27-altered) is a high-grade tumour that grows within the brainstem. Because of its location, surgical removal is not possible. It is one of the most challenging brain tumours in children; active clinical research continues into targeted approaches.

  • Characterised by the H3 K27M mutation in most cases
  • Radiation is the standard approach to control symptoms and slow progression
  • Participation in clinical trials should always be discussed with the treating team
Near the pituitary

Craniopharyngioma

Craniopharyngiomas are slow-growing, usually benign tumours that arise near the pituitary gland at the base of the brain. While not malignant, they can press on the pituitary, hypothalamus, and optic nerves, causing hormonal, vision, and cognitive problems. Management balances tumour control against preserving these critical nearby structures.

  • Two types: adamantinomatous (more common in children) and papillary
  • Treatment involves surgery, radiation, or a combination
  • Long-term hormonal replacement is often needed after treatment
Midline brain

Intracranial germ cell tumours

Germ cell tumours in the brain arise from primordial germ cells that migrated to the brain during early development. They most often occur in the pineal region or the suprasellar area (near the pituitary). They are divided into germinomas and non-germinomatous germ cell tumours, which require different treatment intensities.

  • Germinomas are highly sensitive to both radiation and chemotherapy
  • Tumour markers (AFP, beta-hCG) in blood or CSF assist in diagnosis
  • Often affect pubertal development; endocrine follow-up is important

For a broader view of all childhood cancers treated at CION, visit the Pediatric Cancer overview page.

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The diagnostic and care pathway

How a childhood brain tumour is diagnosed and managed

The journey from first concern to a clear treatment plan involves several steps. Here is what to expect — and what each step is designed to find out.

Recognising the symptoms and seeking review

Most childhood brain tumours are first suspected because of symptoms a parent notices. Morning headaches, vomiting without nausea, double vision, a new squint, difficulty walking, or a change in personality are the most common presentations. Infants may show a rapid increase in head size. If any of these symptoms persist for more than two to three weeks — or worsen rapidly — a prompt evaluation by a paediatrician is the right starting point. The doctor will examine the child’s vision, eye movements, reflexes, and coordination to look for neurological signs that point toward further imaging.

MRI scan with contrast — the essential first image

If a brain tumour is suspected, an MRI (Magnetic Resonance Imaging) scan with gadolinium contrast is the investigation of choice. MRI gives a detailed picture of the tumour’s size, location, relationship to surrounding brain structures, and whether there is swelling (oedema) or bleeding around it. Unlike CT scans, MRI does not use radiation and provides much better soft-tissue detail for the brain. In younger children, the scan is done under sedation or general anaesthesia so the child stays still. In urgent cases where raised pressure inside the skull is suspected, a CT may be done first because it is faster.

Tissue diagnosis — biopsy or surgical resection

An MRI can show that a tumour is present and suggest its likely type, but it cannot tell the team what the tumour cells look like under a microscope, or what molecular alterations they carry. That requires a tissue sample. In most cases, surgery serves two purposes: removing as much of the tumour as safely possible (resection), and sending the removed tissue to the pathologist. Where complete removal is not feasible — for example, in a deep-seated tumour near vital structures — a targeted biopsy using a sterile needle takes a small sample for analysis. Both procedures are performed under general anaesthesia by a paediatric neurosurgeon.

Pathology and molecular testing

The tissue sample is examined under a microscope to identify the tumour cell type and grade (how abnormal the cells look). Critically, it is also tested for specific molecular and genetic markers that the WHO 2021 CNS tumour classification now requires for a complete diagnosis — for example, the H3 K27M mutation (in diffuse midline gliomas), BRAF alterations (in low-grade gliomas), or the WNT/SHH/Group 3/Group 4 subgroup (in medulloblastoma). These markers are not just academic; they directly influence which treatment protocol is most appropriate and what the expected response is likely to be.

Multidisciplinary tumor board review

At CION, every child’s case is presented at a multidisciplinary tumor board meeting before any treatment recommendation is made. This brings together the paediatric medical oncologist, paediatric neurosurgeon, radiation oncologist, neuroradiologist, pathologist, and allied care specialists. Each expert reviews the imaging, pathology, and molecular report and contributes their perspective. The result is a treatment plan that no single specialist could have designed alone. This is what “decisions for healing, not billing” means in practice.

Treatment — surgery, radiation, chemotherapy, or a combination

Treatment depends entirely on the tumour type, grade, location, and the child’s age. Surgery to remove as much of the tumour as safely possible is usually the first step where feasible. For malignant tumours, radiation therapy may follow — but it is generally deferred or avoided in very young children to protect the developing brain. Chemotherapy may be used instead of radiation in very young children, alongside radiation in older children, or as the primary treatment in highly chemosensitive tumour types. Some low-grade tumours that are completely removed may require only close surveillance without further treatment. The team will explain your child’s specific plan at the consultation.

Allied care and long-term follow-up

Brain tumour treatment does not end when the primary therapy is completed. Children who have had a brain tumour need ongoing support: physiotherapy for balance and coordination, speech therapy if swallowing or language is affected, neuropsychological assessment to understand any learning impact, and nutritional support during treatment. Regular MRI surveillance is needed to check for recurrence. Hormonal follow-up is important if the tumour or treatment affected the pituitary gland. The goal is not just to treat the tumour — it is to help the child grow, learn, and thrive after treatment. See also Paediatric Cancer Treatment in Hyderabad for an overview of the full care pathway at CION.

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Common questions

Your questions about brain tumours in children — answered

Are all brain tumours in children cancerous?
No — not all childhood brain tumours are malignant (cancerous). Brain tumours are classified as either benign (non-cancerous, slow-growing, do not invade surrounding tissue) or malignant (fast-growing, may invade and spread). However, even a benign brain tumour can be serious in children because the skull is a closed space: a slow-growing tumour still exerts pressure on delicate developing brain tissue and can cause significant symptoms. The treatment and urgency differ between benign and malignant tumours, but both require careful evaluation and specialist management. The paediatric neuro-oncology team at CION will explain the nature of your child’s specific tumour in the consultation — before any decisions about treatment are made.
What are the warning signs of a brain tumour in a child?
The most common symptoms of a childhood brain tumour are those caused by raised pressure inside the skull: morning headaches that are worst on waking and improve during the day, vomiting in the morning without nausea (often called “breakfast vomiting”), and double vision or a squint. In younger children and infants, look for an unusually rapid increase in head circumference, a bulging fontanelle, or persistent irritability. Other warning signs include new seizures, unexplained changes in balance or walking, personality or behaviour changes, and loss of a skill the child had already learned (such as speaking clearly or writing neatly). These symptoms each have many causes, most of which are not brain tumours. But if any symptom is persistent — particularly morning headaches or unexplained vomiting in a child — a prompt doctor’s review is the right step.
What is the most common brain tumour in children?
The most common brain tumours in children are low-grade gliomas (particularly pilocytic astrocytoma), which are generally slow-growing and often very amenable to treatment. Medulloblastoma — a fast-growing tumour arising at the back of the brain (cerebellum) — is the most common malignant brain tumour in children and a significant focus of paediatric neuro-oncology research and treatment advances. Ependymomas (which arise from the cells lining the brain’s fluid spaces) and brainstem gliomas are also seen in the paediatric age group. Because the treatment approach, urgency, and outlook differ substantially across these types, accurate pathological and molecular diagnosis is essential before any treatment decisions are made.
How is a brain tumour in a child diagnosed?
Diagnosis begins with a detailed clinical assessment by a paediatric neurologist or oncologist, followed by brain imaging — typically an MRI with contrast, which gives the clearest picture of the tumour’s location, size, and relationship to surrounding structures. In most cases, a tissue biopsy (surgical removal of a small piece of the tumour) is needed to confirm the exact type and molecular characteristics of the tumour — because the WHO 2021 classification of CNS tumours now integrates both the tumour’s appearance under the microscope and specific genetic/molecular markers. This molecular information is critical for selecting the most appropriate treatment. In children, this is usually done under general anaesthesia and is carefully planned to minimise any risk to healthy brain tissue.
What treatments are used for brain tumours in children?
Treatment for a childhood brain tumour depends on the tumour’s type, grade, location, size, and the child’s age. Surgery is usually the first step when it is safe and feasible — removing as much of the tumour as possible without harming critical brain areas. Radiation therapy may follow surgery for certain tumour types, though it is generally avoided or deferred in very young children to protect the developing brain. Chemotherapy may be used instead of or alongside radiation, particularly in infants and young children. For some tumours, surveillance (observation) after surgery is appropriate if the tumour is low-grade and has been completely removed. The CION paediatric oncology team reviews every child’s case at a multidisciplinary tumor board — bringing together paediatric oncologists, neurosurgeons, radiation oncologists, and neuroradiologists — before any treatment is recommended. Decisions are never rushed.
Can a child with a brain tumour lead a normal life after treatment?
Many children who are treated for brain tumours do go on to lead meaningful, active lives after treatment. However, the impact of a brain tumour — and its treatment — on a child’s development, cognition, and physical function varies significantly depending on the tumour’s location, type, the child’s age at diagnosis, and the treatments used. This is why paediatric neuro-oncology is a highly specialised field: the goal is not just to treat the tumour, but to preserve the child’s quality of life and developmental potential. Allied care — including physiotherapy, speech therapy, neuropsychological support, and school-reintegration support — plays a vital role alongside medical treatment. The CION team will discuss what to expect for your child specifically, based on their individual situation.

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