Brain tumour treatment in children — surgery, radiation, chemo
Hearing that your child may have a brain tumour is one of the most frightening things a parent can face. You have questions, and you deserve clear answers — not rushed reassurances. At CION, every child's case is reviewed by a team of specialists who have seen these tumours before and plan every step together, for your child specifically.
- Tumor board for every child — medical, surgical, and radiation oncologists plan together before recommending anything
- Coordinated treatment — surgery, brain tumour chemo, and radiation planned as one coherent programme
- 45-minute consultations — no rushed decisions, every question answered, transparent costs
- Psycho-oncology & nutrition support — for your child and for you throughout the journey
Medically reviewed by the CION Pediatric Oncology Team · Last reviewed June 2026
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Types of brain tumours in children — and what each means
Brain tumours in children are not all alike. The tumour's type, location in the brain, and grade all shape what treatment is needed. Here is what the most common types mean in plain language.
Low-grade astrocytoma
These slow-growing tumours arise from star-shaped support cells called astrocytes. The most common is the pilocytic astrocytoma, which typically grows in the cerebellum or optic pathway. When completely removed by pediatric brain tumour surgery, many children need no further treatment. Outcomes are generally very favourable.
Medulloblastoma
A fast-growing tumour that develops in the cerebellum — the part of the brain that controls balance and coordination. It is one of the most common malignant brain tumours in children. Treatment typically involves surgery to remove as much tumour as possible, followed by radiation to the brain and spine, and brain tumour chemo. The treatment plan depends on the child's age and tumour biology.
Ependymoma
Ependymomas arise from cells that line the fluid-filled cavities (ventricles) of the brain and the spinal canal. They can occur at any age in childhood. Surgery is the main treatment; how completely the tumour can be removed significantly affects what comes next. Radiation is often used after surgery. Some cases need chemotherapy as well.
Craniopharyngioma
Craniopharyngiomas are benign (non-cancerous) tumours that grow near the pituitary gland and the optic nerve. They can affect hormone production, vision, and weight regulation. Despite being benign, they can be challenging to treat because of their location. Management may involve surgery, radiation, or a combination, with careful attention to preserving hormonal and visual function.
Brainstem glioma (DIPG / DMG)
Brainstem gliomas arise within the brainstem — the part of the brain that controls breathing, heart rate, and swallowing. Diffuse intrinsic pontine glioma (DIPG, now called diffuse midline glioma or DMG) is the most serious form. Because of its location, surgery is usually not possible. Radiation is the primary treatment, with chemotherapy used in some protocols. Research in this area is active and evolving.
High-grade glioma (HGG)
High-grade gliomas in children grow more quickly than low-grade types and require more intensive treatment. Surgery aims to remove as much tumour as safely possible. This is typically followed by radiation and brain tumour chemo in a structured programme planned by the multidisciplinary team. Genetic testing of the tumour now guides which treatment protocols are most likely to help.
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17+ senior cancer specialists. One panel for your case.
Trained at AIIMS, Tata Memorial, and leading international centres. Combined 150+ years of experience. Every complex case is reviewed by 3+ of them — together.
Dr. C. Raghavendra Reddy
MBBS(Gold Medal), DNB(General Medicine), DM(Medical Oncology)(Gold Medal)
Dr. Bharati Devi Gorantla
MBBS, MD(General Medicine), DM(Medical Oncology)(Adyar,Chennai), ECMO, MRCP SCE(UK)
Dr. Owais Mohammed
MBBS, MD (General Medicine), DrNB (Medical Oncology), ECMO, MRCP SCE (Medical Oncology) (UK)
Dr. Muralidhar Muddusetty
MBBS (AIIMS), MS (Surgery) (AIIMS), DNB (Surgical Oncology), MRCS (Edinburgh)
Dr. Vinay Mamidala
MBBS, MS(General Surgery), M.Ch(Surgical Oncology), FMAS, FARIS(Ongoing)
Dr. Mohammed Imran
Dr. Vajja Sandeep Kumar
MBBS, MS (General Surgery), DrNB (Surgical Oncology), FALS Oncology
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How brain tumour treatment in children works — step by step
No two children's treatment plans are exactly alike. But the broad shape of the journey — from first evaluation through to follow-up — follows a structured path that your team will explain at every stage.
MRI scan and initial evaluation
If a brain tumour is suspected — usually because of persistent morning headaches, repeated vomiting, visual changes, balance problems, or other warning signs — the first step is a detailed MRI scan of the brain (and often the spine). An MRI gives the team a clear picture of where the tumour is, how large it is, and whether it has spread to the fluid around the brain and spine. This information shapes every decision that follows. A specialist radiologist reviews the images and reports to the oncology team. At this stage, no treatment is started — the team first needs to understand exactly what they are dealing with.
Neurosurgical consultation and biopsy or resection
Once the MRI is reviewed, the child is seen by a neurosurgeon who specialises in brain tumours. For most tumours, surgery serves two purposes: to obtain a tissue sample so the tumour can be precisely identified (biopsy), and — where it is safe to do so — to remove as much of the tumour as possible (resection). How much can be safely removed depends on the tumour's location and proximity to vital brain regions. The neurosurgery team will explain clearly what is planned, what the risks are, and what to expect after the operation. Pediatric brain tumour surgery is performed under general anaesthesia, and children are typically in hospital for several days to a week afterwards.
Pathology and molecular testing
The tissue removed during surgery is sent to a pathologist, who examines it under a microscope to confirm the tumour type and grade. In addition to standard microscopy, the sample is now routinely tested for specific genetic and molecular markers — such as IDH mutation status, 1p/19q co-deletion, BRAF alteration, and H3 K27M mutation in midline tumours. These markers are not just labels — they determine which treatment protocol the child should receive and, in some cases, which targeted therapies may be an option. This is why an accurate pathology report from a centre with the right laboratory capability matters so much at this stage.
Multidisciplinary tumor board review
Before any further treatment is recommended, every child's case is presented at CION's multidisciplinary tumor board. This means the medical oncologist, neurosurgical oncologist, radiation oncologist, pathologist, and radiologist all review the case together. The board considers the tumour type, grade, molecular profile, the child's age, and what was achieved at surgery — and agrees on a treatment plan as a team. Parents are then given a clear, written plan explaining what is recommended and why. No decision is made by a single doctor alone. This is the CION standard for every patient, not just for difficult cases.
Radiation therapy — when and how it is used
Radiation therapy uses precisely targeted beams of energy to destroy remaining tumour cells after surgery. For many paediatric brain tumours — including medulloblastoma and high-grade gliomas — radiation is a core part of the treatment programme. Modern radiation planning allows the beam to be shaped very precisely around the tumour, minimising the dose to surrounding healthy brain tissue. In children under three years old, the team will usually use chemotherapy first and delay radiation while the brain continues to develop. The radiation oncologist will explain the total dose, the number of sessions (which are given daily, Monday to Friday, usually over four to six weeks), and how your child will be positioned for each treatment session.
Chemotherapy — structured cycles with close monitoring
Brain tumour chemotherapy in children is used in combination with radiation for some tumour types, or as the primary medical treatment — particularly in younger children where radiation needs to be deferred. Chemotherapy is given in cycles: a period of treatment followed by a rest period, repeated over several months. It is administered as an intravenous infusion at the clinic, or in some regimens as oral tablets taken at home. Throughout the chemotherapy programme, your child will have regular blood tests and periodic scans to monitor the response to treatment and to check for side effects. The team will explain what side effects are expected with the specific regimen your child will receive, and how they will be managed.
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Post-treatment monitoring and follow-up
After active treatment ends, regular follow-up is essential. The schedule of follow-up MRI scans, blood tests, and clinical check-ups is designed to catch any sign of tumour return as early as possible, and to monitor for the late effects of treatment. Some children need endocrine (hormone) check-ups, neuropsychological assessment, or physiotherapy as part of their follow-up care. The CION team will give you a clear follow-up plan before your child's treatment ends, so you know what to expect and when to come back. You will also be given clear guidance on what signs to watch for at home and when to call the clinic.
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