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Targeted Therapy

Targeted Therapy at CION Cancer Clinics — A Complete Guide

Everything we have written about targeted therapy in one place: what it is, the tests that decide whether it can help you, what treatment is actually like, the side effects that matter, and what it costs in India. Written for patients and families, reviewed by oncologists.

Medically reviewed by Dr. T. Raghavender Reddy, Medical Oncologist, MBBS · DM (Medical Oncology) · MD (Radiation Oncology) · Last reviewed August 2026

  • Start here — What it is, how it works and whether it applies to your cancer.
  • Before you start — The tests that decide eligibility, and what the results mean.
  • During treatment — Side effects, what is normal, and what needs a call today.
  • Cost and access — What it costs in India, and the schemes that may apply.
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Targeted therapy is cancer treatment aimed at a specific change inside the cancer cell rather than at all fast-dividing cells. It only works if your cancer carries the change the drug targets, which is why a biomarker or molecular test comes first. If the test is negative, this class of treatment is not the right one for you, and that is worth knowing early.

How targeted therapy is different from chemotherapy

Chemotherapy works on cells that divide quickly. Cancer cells do, which is why it works, but so do the cells in your hair follicles, your gut lining and your bone marrow, which is why it causes the side effects it does.

A targeted therapy is built around one specific fault in the cancer cell. If that fault is present, the drug can interrupt it while leaving far more healthy tissue alone. The side effects are usually different rather than simply fewer: skin, gut, blood pressure and thyroid problems are common, and some need attention quickly.

This is also why targeted therapy cannot be prescribed on the basis of your cancer type alone. The test result decides it.

Where to start, depending on where you are

  • Just diagnosedRead what targeted therapy is, then what biomarker testing involves and how long results take.
  • Waiting for a molecular reportUnderstand what the test looks for, and what happens if it comes back negative.
  • About to start treatmentLook at the baseline checks, what the first weeks feel like, and what to have at home.
  • Already on treatmentGo to the symptom you are dealing with. Each page says what is ordinary and what needs a call today.
  • Worried about costStart with the cost and access pages, including which government schemes may apply.
  • Told it has stopped workingRead about resistance and what the next line of treatment involves.

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We have centres across Telangana and Andhra Pradesh. Tell us where you are and we will point you to the closest one that offers what you need.

Meet the Specialists

17+ senior cancer specialists. One panel for your case.

Trained at AIIMS, Tata Memorial, and leading international centres. Combined 150+ years of experience. Every complex case is reviewed by 3+ of them — together.

Dr. Naresh Gundu
Medical Oncologist

Dr. Naresh Gundu

MBBS, DNB (Internal Medicine), DM (Medical Oncology)

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Dr. C. Raghavendra Reddy
Medical Oncologist

Dr. C. Raghavendra Reddy

MBBS(Gold Medal), DNB(General Medicine), DM(Medical Oncology)(Gold Medal)

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Dr. Bharati Devi Gorantla
Medical Oncologist

Dr. Bharati Devi Gorantla

MBBS, MD(General Medicine), DM(Medical Oncology)(Adyar,Chennai), ECMO, MRCP SCE(UK)

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Dr. Owais Mohammed
Medical Oncologist

Dr. Owais Mohammed

MBBS, MD (General Medicine), DrNB (Medical Oncology), ECMO, MRCP SCE (Medical Oncology) (UK)

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Dr. T. Raghavender Reddy
Medical Oncologist

Dr. T. Raghavender Reddy

MBBS, DM (Medical Oncology), MD (Radiation Oncology)

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Dr. N. Kiranmayee
Medical Oncologist

Dr. N. Kiranmayee

MBBS, DM (Medical Oncology), MD (Internal Medicine)

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Dr. Muralidhar Muddusetty
Surgical Oncologist

Dr. Muralidhar Muddusetty

MBBS (AIIMS), MS (Surgery) (AIIMS), DNB (Surgical Oncology), MRCS (Edinburgh)

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Dr. Raghavendra Naik
Surgical Oncologist

Dr. Raghavendra Naik

MBBS, MS (General Surgery), M.Ch (Surgical Oncology)

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Dr. Mohammed  Imaduddin
Surgical Oncologist

Dr. Mohammed Imaduddin

M.B.B.S, MS (General Surgery), M.Ch (Surgical Oncology)

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Dr. Vinay Mamidala
Surgical Oncologist

Dr. Vinay Mamidala

MBBS, MS(General Surgery), M.Ch(Surgical Oncology), FMAS, FARIS(Ongoing)

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Dr. Paila Gowri Naidu
Surgical Oncologist

Dr. Paila Gowri Naidu

MBBS, MS (General Surgery), M.Ch (Surgical Oncology), FMAS

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Dr. Venkata Sushma P
Radiation Oncologist

Dr. Venkata Sushma P

MBBS, MD (Radiation Oncology)

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Dr. Kirti Ranjan Mohanty
Radiation Oncologist

Dr. Kirti Ranjan Mohanty

MBBS, MD (Radiation Oncology)

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Dr. Gangadhar Vajrala
Radiation Oncologist

Dr. Gangadhar Vajrala

MBBS, MD (Radiation Oncology), MPH

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Dr. Basudev Pokhrel
Hematologist

Dr. Basudev Pokhrel

MBBS, M.D (Immunohematology & Blood Transfusion)

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Dr. Mohammed Imran
Interventional Radiologist

Dr. Mohammed Imran

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Dr. Vajja Sandeep Kumar
Surgical Oncologist

Dr. Vajja Sandeep Kumar

MBBS, MS (General Surgery), DrNB (Surgical Oncology), FALS Oncology

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Dr. Sridhar Kamani
Surgical Oncologist

Dr. Sridhar Kamani

MBBS, MS (General Surgery), DrNB (Surgical Oncology)

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The one thing worth knowing before anything else

Targeted therapy is not a better version of chemotherapy that everyone should ask for. It is a treatment for a specific molecular finding, and many people who are tested will not carry the change a given drug needs.

That is not a failure of the test or of your care. Knowing early means you and your team can put your attention on the treatment that will help, instead of pursuing one that cannot.

Terms you will meet

Biomarker
A measurable feature of your cancer, usually a gene change or a protein, that predicts whether a particular drug can work.
Mutation
A change in the cancer cell DNA. Some mutations are the fault a targeted therapy is designed to interrupt.
NGS
Next-generation sequencing: a test that reads many genes at once rather than checking them one at a time.
Resistance
When a treatment that was working stops working, because the cancer has found a way around the drug.
Line of treatment
First line is the first treatment tried; second line is what follows if the first stops working.

Explore 881 more targeted therapy topics

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Drug Deep Dive: Trastuzumab Deruxtecan (Enhertu)

Mutation & Target-Specific Pages

Side Effects - Symptom-Specific Deep Dives

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Common questions

Frequently asked questions

What is targeted therapy in simple terms?

It is cancer treatment aimed at one specific fault inside the cancer cell, rather than at all rapidly dividing cells the way chemotherapy is. Because it is built around that fault, it can only help if your cancer actually carries it. A biomarker or molecular test is done first to find out, and the result decides whether this class of treatment is an option for you at all.

How do I know if targeted therapy will work for me?

A test on your tumour tissue, or sometimes on blood, looks for the specific change the drug is designed to act on. If that change is present, your oncologist can consider a matching drug. If it is absent, targeted therapy is not the right treatment, and pushing for it would delay one that could help. Ask your team which test was done and what it looked for.

Is targeted therapy better than chemotherapy?

Neither is better in general; they do different jobs. For someone whose cancer carries the right change, a targeted therapy can be more effective and easier to live with. For someone whose cancer does not, chemotherapy may be the treatment that works. Many people receive both at different stages. The comparison that matters is the one for your cancer, which your oncologist can explain.

What side effects should I expect?

They are usually different from chemotherapy rather than simply milder. Skin rashes, diarrhoea, changes to nails and hair, raised blood pressure, and thyroid or liver changes are all common depending on the drug. Most are manageable when reported early. A few, such as breathlessness, severe rash with fever, or diarrhoea with blood, need to be reported the same day rather than waited out.

Can I take targeted therapy tablets at home?

Many targeted therapies are tablets taken at home, which is one of their advantages. That also puts more responsibility on you: taking them consistently, keeping to any food rules your team gives you, telling them about every other medicine or supplement you take, and reporting side effects rather than stopping on your own. Other targeted therapies are given as infusions in a day-care setting.

Do herbal or ayurvedic medicines interfere with targeted therapy?

They can, and it is one of the more common avoidable problems. Some herbal preparations change how quickly your liver clears a cancer drug, which can make the drug too strong or too weak without anyone realising. This is not about whether the herb is safe on its own. Tell your oncologist and pharmacist about everything you take, including supplements bought without a prescription.

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