Periods, menopause and hormones
Hormonal effects in men
Chemotherapy can affect the testes, lowering testosterone in some men. This can cause tiredness, low desire, erection problems, low mood, reduced muscle strength and hot flushes. It is under-recognised because most information focuses on women. Levels often improve after treatment, but not always, and a simple blood test can check.
The short answer
Can chemotherapy lower testosterone in men?
Yes, in some men. The testes have two main jobs: making sperm and making testosterone. Chemotherapy most often affects sperm production, but some medicines, particularly at higher total amounts, and treatments such as radiotherapy near the testes or high-dose treatment before a stem cell transplant, can also reduce the cells that make testosterone. Steroids, opioid painkillers, weight loss and serious illness can lower testosterone too. Separately, hormone treatment for prostate cancer deliberately lowers testosterone to control the cancer, which causes similar effects by design.
Low testosterone can cause tiredness, low desire, erection difficulties, low mood, irritability, poor concentration, loss of muscle strength, weight gain around the middle, hot flushes and sweats, and, over time, bone thinning. Many of these overlap with the general effects of cancer and its treatment, so hormonal causes are easily missed. Almost all information about hormonal effects of chemotherapy focuses on women, and men are rarely asked. A simple morning blood test can check testosterone. In many men levels recover in the months or years after treatment, but not in all. Whether testosterone treatment is appropriate depends on the type of cancer, because it is unsafe after some cancers, including prostate cancer, and must be decided with your oncologist and a specialist.
Symptoms are easy to dismiss
Men often put tiredness and low desire down to cancer or stress. Mentioning them allows testing.
Sperm and testosterone are different
Normal testosterone does not mean normal fertility, and low sperm counts can occur with normal testosterone.
Young men and teenagers
Treatment during or before puberty can affect development and needs specialist follow-up.
If you notice ongoing tiredness, low desire, erection problems or loss of strength after treatment, ask your team whether testosterone should be checked.What are the symptoms
Signs of low testosterone
- Energy and mood
- Persistent tiredness, low mood, irritability and poor motivation.
- Sexual health
- Low desire, fewer morning erections and erection difficulties.
- Body changes
- Loss of muscle strength, weight gain around the tummy and breast tenderness or enlargement.
- Hot flushes and sweats
- Especially with hormone treatment for prostate cancer, but can occur with low testosterone from other causes.
- Concentration
- Brain fog and poor focus, adding to treatment effects.
- Bones
- Over time, thinning bones and higher fracture risk, often without symptoms.
Not sure whether this applies to you?
Ask an oncologistDoes it recover
How low testosterone is checked and followed
Describe your symptoms
Tell your team about tiredness, desire, erections, mood and strength, and when they started.
Morning blood test
Testosterone is highest in the morning, so tests are usually done early in the day, often repeated.
Check related hormones
Other hormones help show whether the testes or the brain signals are affected.
Review over time
Levels may be rechecked months later, as recovery can be slow.
Discuss options
If levels stay low, your oncologist and a specialist discuss whether treatment is safe and helpful.
Feeling hopeless or thinking of harming yourself · a new lump or swelling in a testicle · sudden severe pain in the testicles · an erection lasting several hours · sudden severe back pain after a minor fall · chest pain or breathlessness. Contact your team the same day, and go to the nearest emergency department for severe pain, a prolonged erection, chest pain or thoughts of self-harm.
Being straight with you
What this page cannot tell you
It cannot tell you whether your testosterone is low or whether it will recover. That needs blood tests, often repeated, and depends on your treatment and age.
It also cannot tell you whether testosterone treatment is safe for you. It is unsuitable after some cancers, and has its own risks. That decision belongs with your oncologist and a specialist.
Do not buy testosterone products
Products sold online or in gyms may be unsafe and can interfere with cancer care.
Fertility is a separate question
Ask about sperm banking before treatment, and semen testing afterwards if you want children.
Lifestyle helps
Regular exercise, a healthy weight, good sleep and limiting alcohol support testosterone and wellbeing.
Mood deserves attention
Low mood may be hormonal, emotional or both. Counselling and treatment can help.
Bone health
Men with long-term low testosterone may need bone checks.
Prostate cancer hormone treatment
Men on this treatment have specific advice about exercise, bones and heart health. Ask your team.
Partners can help notice changes
Partners often notice mood or energy changes first. Their observations are useful.
Talking about it
Many men find these topics hard to raise. Doctors are used to them.
Why men often go unrecognised
Most discussion of hormonal effects after cancer treatment focuses on women, so men and their doctors may not think of testosterone when tiredness, low mood or low desire persist. Men may also be reluctant to raise symptoms about sex or strength, and may put them down to getting older or to the stress of cancer. As a result, low testosterone can go untested for a long time. Mentioning a cluster of symptoms, such as ongoing tiredness together with low desire and loss of strength, makes it more likely that a test will be considered.
Exercise and strength after treatment
Regular strength exercise, even at home with simple movements or light weights, helps rebuild muscle lost during treatment, supports bones, improves energy and mood, and may help testosterone levels. Start gently and build up gradually, especially if you are still tired or have nerve symptoms, and ask a physiotherapist for a safe plan if you have heart problems or thin bones.
Emotional wellbeing for men
Many men find it hard to talk about feeling low, anxious or less confident after cancer. Counselling, support groups for men, or a conversation with a trusted friend can help, and treating low mood often improves energy and desire as well.
What partners and families may notice
Wives, partners and adult children are often the first to notice that a man seems flatter, more irritable, less interested in things he used to enjoy, or physically weaker after treatment. They may also notice changes in sleep, weight or confidence. These observations can be very helpful to doctors, especially when a man finds it hard to describe how he feels. Bringing a family member to a follow-up appointment, or writing down what they have noticed, gives the team a fuller picture and makes it more likely that hormonal causes will be checked.
Work, energy and daily life
Low testosterone, tiredness and low mood can make returning to work, running a business or providing for a family feel much harder. Planning a gradual return, taking short breaks, prioritising important tasks and being open with employers where possible can help. If energy does not improve over time, asking for hormone and thyroid tests, and for support with mood, is a sensible step rather than simply pushing through.
What to do next
Tell your team about tiredness, low desire, erection problems, mood changes or loss of strength, ask whether a morning testosterone test is needed, avoid unregulated products, look after exercise, sleep and weight, and discuss fertility and bone health.
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Commonly believed
Four beliefs about hormones in men
Men can have low testosterone after treatment too.
Low testosterone, thyroid problems or low mood may contribute and can be checked.
They are unsafe after some cancers and must be medically supervised.
Sperm production can be affected even when erections and testosterone are normal.
Questions we are asked
Common questions about hormonal effects in men
Does testosterone fall during chemotherapy?
In some men, yes, especially with certain medicines, higher total amounts or radiotherapy near the testes.
What are the symptoms?
Tiredness, low desire, erection problems, low mood, loss of strength, weight gain and hot flushes.
Does it recover?
Often, over months or longer, but not always. Repeat tests show the trend.
How is it tested?
With a morning blood test, sometimes repeated, and related hormone tests.
Can I have testosterone treatment?
It depends on your cancer. It is unsafe after prostate cancer and some others.
Does it affect fertility?
Fertility is separate. Ask about semen testing if you want children.
Can lifestyle help?
Yes. Exercise, healthy weight, sleep and limiting alcohol support hormones.
Who should I talk to?
Your oncologist, who can refer you to an endocrinologist or urologist.
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Sources
- American Cancer Society — How Cancer and Cancer Treatment Can Affect Fertility in Men
- Macmillan Cancer Support — Hormonal symptoms in men
- National Cancer Institute — Late Effects of Cancer Treatment
This page is general information, not a prescription. Do not change or stop any treatment based on what you read here. If anything is worrying you, contact your own treating team — or call our helpline and we will help you reach the right specialist.
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