Tests and organ effects
Monitoring for organ effects: the tests explained
Before and during chemotherapy, regular tests check that your heart, kidneys, liver, lungs, hearing and blood counts are coping with treatment. Most are simple blood tests; others are scans or hearing checks, chosen according to your medicines. They let your team spot changes early and adjust treatment before a problem becomes serious.
The short answer
Which tests check your organs during chemotherapy?
Before and during chemotherapy, your team uses a set of tests to check that your body is coping. Blood tests are the most common: they check blood counts, kidney function, liver function and salts, usually before each cycle. Depending on your medicines, you may also have heart scans, heart tracings, hearing tests, breathing tests, thyroid blood tests, urine tests, or checks of your nerves and eyes. Not everyone needs every test; the schedule is built around the medicines you receive and your own health.
These tests are how problems are caught early, often before you have any symptoms. A falling blood count may delay a cycle by a few days; a change in kidney function may lead to a lower dose or extra fluids; a drop in heart pumping strength may pause a particular medicine. The aim is always to keep treating the cancer as safely as possible. How often each test is repeated is decided by your team, and it is reasonable to ask why a test is being done.
Baseline tests come first
Tests before treatment set a starting point, so later results can be compared and small changes spotted.
Results guide each cycle
Blood results are usually reviewed before every cycle to decide whether it is safe to go ahead.
Symptoms still matter
Tests do not replace reporting symptoms. Tell your team about new problems between tests.
Keep copies of your test reports in one file and bring it to every appointment, especially if tests are done at different labs.Organ by organ
The monitoring tests and what they check
- Bone marrow: complete blood count
- Checks white cells, red cells and platelets, usually before each cycle. Low counts can delay treatment, lead to a dose change or growth factor support.
- Kidneys: creatinine, salts and urine tests
- Blood and urine tests show how well the kidneys are filtering. Especially important with cisplatin, methotrexate and ifosfamide. Changes may lead to extra fluids or dose adjustments.
- Liver: liver function tests
- Blood tests of liver enzymes and bilirubin. Many medicines are processed by the liver, so abnormal results can mean a dose change or a pause.
- Heart: echo scan, ECG and blood pressure
- Used with anthracyclines, HER2-targeted treatments and some targeted tablets. A drop in pumping strength or rhythm changes can pause treatment.
- Lungs: breathing tests and scans
- Used with bleomycin and when symptoms suggest lung effects. Changes may lead to stopping a medicine or starting steroids.
- Ears, thyroid, nerves and eyes
- Hearing tests with platinum medicines, thyroid blood tests with immunotherapy and some targeted treatments, nerve symptom checks with taxanes and oxaliplatin, and eye checks with certain targeted medicines.
Not sure whether this applies to you?
Ask an oncologistWhat triggers a change
How test results shape your treatment
Tests are done before the cycle
Usually a day or two before, or on the morning of treatment, so results are ready when your doctor reviews you.
Results are compared with safe limits
Your team checks whether each result is within the range considered safe for your particular medicines.
Treatment goes ahead, waits or changes
If results are acceptable, treatment continues. If not, it may be delayed, the dose adjusted, or a medicine changed.
Extra support may be added
Fluids, growth factor injections, heart medicines, thyroid tablets or steroids may be given depending on the result.
Tests are repeated
Abnormal results are rechecked to confirm recovery before the next step.
Fever or shivering · chest pain or sudden breathlessness · passing very little urine or none · yellowing of the eyes or skin · confusion or extreme drowsiness · sudden hearing loss · bleeding that will not stop · a swollen, painful leg. Call your chemotherapy helpline or go to the nearest emergency department and say clearly that the person is on or has had chemotherapy.
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Being straight with you
What this page cannot tell you
It cannot tell you exactly which tests you need or how often. Schedules vary with your medicines, cancer type, age and other conditions, and your team sets them. It also cannot interpret your results, because the same number can mean different things for different treatments.
It cannot tell you to delay or skip a test. Missed tests can delay treatment or allow problems to go unnoticed. If you cannot attend, contact your team to rearrange.
Why tests are repeated so often
Organ function can change between cycles. Repeat testing keeps treatment safe as your body responds.
Testing at a local lab
If you have blood tests near home, send results to your team in time and keep the same lab where possible so values are comparable.
Fasting and timing
Some tests need fasting or timing around medicines. Ask whether you need to prepare, and whether to take morning tablets first.
Hydration affects kidney results
Being dehydrated can make kidney tests look worse. Drink fluids as advised before testing unless told otherwise.
Long-term monitoring after treatment
Some tests, such as heart scans, thyroid tests and hearing checks, may continue after treatment ends, depending on the medicines you had.
Costs add up
Regular tests are a real expense. Ask your team which are essential and whether they can be combined with visits.
Ask what each result means
It is reasonable to ask whether results are normal, what any change means, and whether anything needs to be done.
Keep a results file
A single file of reports helps any doctor, including in an emergency, understand how your organs have coped with treatment.
Urine tests are part of monitoring
With some medicines, such as ifosfamide and cyclophosphamide, urine may be checked for blood or protein. Collect samples as instructed and tell your team if the urine looks pink, red or unusually dark.
Blood sugar checks on steroids
Steroids given with chemotherapy can raise blood sugar, even in people without diabetes. Your team may check sugar levels, especially if you feel very thirsty, pass a lot of urine or feel unusually tired.
Weight is monitored too
Doses of many medicines are based on your weight and height. Significant weight loss or gain can change doses, so weigh-ins at each visit matter.
What to do next
Ask your team which monitoring tests you need and why, keep every test appointment, prepare as advised, and keep a file of your results. Report new symptoms between tests, and seek help the same day for warning signs rather than waiting.
Commonly believed
Four beliefs about monitoring tests
Regular tests are routine safety checks for most chemotherapy. They are how problems are prevented, not a sign of one.
Low counts and kidney or liver changes often cause no symptoms. Tests are needed to treat safely.
Delays for low counts or organ results are common and protect you. They do not usually mean treatment is not working.
Monitoring is tailored to your medicines and health. Your tests may differ from someone else in the day care unit.
Questions we are asked
Common questions about organ monitoring
Which tests are done during chemotherapy?
Blood counts, kidney and liver tests for most people, plus heart, hearing, lung, thyroid or other tests depending on your medicines.
How often are tests done?
Blood tests are usually before each cycle. Other tests depend on your medicines and results. Your team will explain your schedule.
What are the tests checking?
Whether your bone marrow, kidneys, liver, heart and other organs are coping, so treatment stays safe.
What happens if a result is abnormal?
Treatment may be delayed, the dose adjusted, a medicine changed, or extra support given. Tests are then repeated.
Can I get blood tests done near home?
Often yes. Ask your team which tests are needed and make sure results reach them in time before treatment.
Do I need to fast before tests?
Most chemotherapy blood tests do not need fasting, but some do. Ask your team before each new test.
Will monitoring continue after treatment?
Some tests may, depending on your medicines, such as heart, thyroid or hearing checks.
Can I see my results?
Yes. Ask for copies, ask what they mean, and keep them in one file for future doctors.
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Sources
- National Cancer Institute — Late Effects of Cancer Treatment
- Cancer Research UK — Side effects of chemotherapy
- American Cancer Society — Long-term Side Effects of Cancer Treatment
This page is general information, not a prescription. Do not change or stop any treatment based on what you read here. If anything is worrying you, contact your own treating team — or call our helpline and we will help you reach the right specialist.
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