Breast cancer care across CION centres in Hyderabad · ArogyaSri, CGHS & cashless insurance accepted · Call 1800 202 8726

Treatment options

Lumpectomy when the tumour cannot be felt

Many breast cancers are found on a mammogram or ultrasound before they can be felt. To remove them, the area is marked beforehand with a wire, seed or ultrasound guidance. This page explains how localisation works, what the day involves, the honest limits and what recovery looks like.

Call 1800 202 8726

Speak to an oncologist

Book a consultation

Talk to a breast cancer specialist at a CION centre near you.

Free call back. Your details stay private.

MM
Medically reviewed by Dr. Muralidhar MuddusettyConsultant Surgical Oncologist · MBBS (AIIMS), MS (Surgery, AIIMS), DNB (Surgical Oncology), MRCS (Edinburgh) · last reviewed September 2026, next review due September 2027
17+specialists on panel
15,000+patients treated
35+centres across Telangana & AP
4.8★ / 800+Google rating

The short answer

How is a lumpectomy done when the tumour cannot be felt?

Many breast cancers today are found on a mammogram or ultrasound before they can be felt as a lump. These are called non-palpable tumours. They may be small, show up only as a group of tiny calcium specks, or have shrunk after chemotherapy given before surgery. Finding them early is good news, because smaller cancers are often easier to treat and more suitable for breast conservation. The challenge is that the surgeon cannot find the area by touch during the operation, so it has to be marked beforehand. This process is called localisation. Usually, a small metal marker clip is placed in the tumour at the time of biopsy. Then, shortly before surgery or on an earlier day, a radiologist uses mammogram or ultrasound guidance to place a guide. This can be a thin wire whose tip sits in the tumour, a tiny seed or reflector that a handheld probe can detect, or an ink or skin mark for tumours clearly seen on ultrasound. In some centres the surgeon uses ultrasound directly in the operating theatre. After removal, the tissue is often X-rayed straight away to confirm the marker and target area are inside it. The rest of the lumpectomy, recovery and results are much the same as for a lump that can be felt. Localisation takes a little extra time, but it lets your surgeon remove the right area precisely while keeping as much healthy breast as possible.

Early detection is common

Screening often finds cancers before any lump forms.

The area is marked first

A wire, seed or ultrasound mark guides the surgeon to the exact spot.

The tissue is checked immediately

An X-ray of the removed tissue confirms the target was taken out.

This page gives general information only. Methods vary between hospitals, and your team will explain theirs.

How it is found

Ways to guide the surgeon to a hidden tumour

Your team chooses based on what is available, where the tumour is and how clearly it shows on imaging.

Wire localisation

A fine wire is placed through the skin into the tumour using mammogram or ultrasound, usually on the day of surgery. The surgeon follows the wire to the target.

Seed or reflector localisation

A tiny marker, magnetic, radar-reflecting or mildly radioactive, is placed in the tumour days or weeks ahead. A handheld probe finds it during surgery.

No wire sticks out of the breast while you wait.

Ultrasound-guided surgery

If the tumour shows well on ultrasound, the surgeon or radiologist can scan the breast in theatre and remove the area under direct view.

Marker clip

A small clip placed during biopsy stays in the tumour so it can always be found again.

Especially useful when

  • Chemotherapy is given before surgery
  • The tumour is very small
  • Only calcium specks show the cancer

Not sure whether this applies to you?

Ask an oncologist

Step by step

What usually happens on the way to surgery

Step What to expect
Biopsy and clip A needle biopsy confirms cancer, and a tiny clip is usually left to mark the spot
Localisation A radiologist places a wire, seed or skin mark using local anaesthetic and imaging
Check mammogram A quick image confirms the guide is in the right place
Surgery Under general anaesthetic, the surgeon removes the marked area with a rim of healthy tissue
Specimen X-ray The removed tissue is imaged to confirm the clip and target are inside before you wake

Words you may hear

The vocabulary, in plain language

Non-palpable
Cannot be felt by hand, only seen on scans.
Localisation
Marking the exact position of a tumour before surgery.
Microcalcifications
Tiny calcium specks on a mammogram that can sometimes signal DCIS or early cancer.
Specimen radiograph
An X-ray of the removed tissue taken during the operation.
Stereotactic biopsy
A needle biopsy guided by mammogram images, used when a change shows only on mammography.
Margins
The edges of the removed tissue, checked to see whether cancer reaches them.

Leave a number, we will call you

One field. No form to fill in, and no charge for the call.

Talk to our team

Have a question about your situation?

Call the helpline or leave your details, and someone will help you arrange a consultation at the CION centre nearest you. One helpline serves every CION centre.

Call 1800 202 8726 Helpline open 24/7

Request a call back

Share your number and a specialist's team will call you.

Free call back. Your details stay private.

Being straight with you

Honest realities about non-palpable tumours

Localisation works well in most cases, but there are some points worth knowing.

Margins can still be close

When cancer shows only as calcium specks, its true extent can be harder to judge, so a second operation for margins is sometimes needed.

The day can be long

Wire placement and surgery on the same day may involve waiting between departments.

Guides can occasionally move

A wire or seed may shift slightly, though the specimen X-ray helps catch this during surgery.

What this page cannot tell you

It cannot tell you which method your hospital uses. Ask your team how your tumour will be marked.

Getting ready

Preparing for localisation and surgery

Knowing what the extra step involves can make the day feel calmer.

Wear a front-opening top

You will change for the mammogram and again for surgery, so easy clothing helps.

Expect some pressure

The breast may be held in the mammogram machine for a while during placement. Local anaesthetic numbs the skin, and most women describe discomfort rather than sharp pain.

Protect the wire

If a wire is used, it is taped down. Avoid pulling on it or lifting your arm high until surgery.

Follow fasting instructions

Localisation does not change the fasting rules for general anaesthetic, so follow what you were told.

Mention metal implants or pacemakers

These can matter if a magnetic seed is planned, so tell the radiologist in advance.

After the operation

Recovery and results

Once the tissue is out, the rest of your journey is similar to any lumpectomy.

Recovery is similar

Soreness, bruising and a small scar are usual. The wire or seed site does not need separate care.

The final report matters

The laboratory checks tumour size, type and margins. This decides whether more surgery is needed.

Radiation usually follows

As with other lumpectomies, radiation to the breast is often recommended afterwards.

Commonly believed

What people assume about tumours you cannot feel

If you cannot feel it, it cannot be serious.

Non-palpable cancers are real cancers, but finding them early often helps.

A tumour you cannot feel needs a mastectomy.

Localisation allows many of these tumours to be removed by lumpectomy.

The marker clip must be removed later.

It is usually taken out with the tumour, and any left behind is harmless.

The surgeon is guessing where to cut.

Imaging guides and a specimen X-ray confirm the right area is removed.

Questions we are asked

Common questions about lumpectomy for a non-palpable tumour

Does wire placement hurt?

Local anaesthetic is used to numb the skin, so most women feel pressure and mild discomfort rather than sharp pain. Being held in the mammogram machine can be the most uncomfortable part. Tell the radiologist if you feel faint or need a short break during the procedure.

How long does the wire stay in?

A wire is usually placed a few hours before surgery on the same day and removed with the tissue during the operation. You will wait with it taped in place. Seeds and reflectors can be placed days or weeks earlier because nothing sticks out of the skin.

Is a radioactive seed dangerous?

Seeds used for localisation contain a very small amount of radioactivity, far less than a treatment dose. They are removed during surgery. Many centres now use non-radioactive magnetic or radar seeds instead. Your team will explain any precautions if one is used.

Can the metal clip set off airport scanners?

No. Biopsy marker clips are tiny and do not trigger airport metal detectors. They are also generally safe for MRI scans. Keep a note that you have one in case a future radiologist asks about it.

Why do I need a mammogram on the day of surgery?

A quick mammogram after placing the wire or seed confirms it is in exactly the right place. This gives your surgeon a clear map to follow and lowers the chance of missing the target area or removing more tissue than needed.

Is the risk of a second operation higher?

It can be a little higher, particularly when cancer shows only as calcium specks whose edges are hard to see. Some surgeons take extra shavings from the cavity walls to reduce this. Your surgeon can explain how they approach margins in your case.

What if chemotherapy has made the tumour disappear on scans?

This is why a marker clip is placed before chemotherapy. Even if the tumour can no longer be seen, the clip shows where it was, so the surgeon can still remove that area and the laboratory can check for any remaining cancer cells.

Will I need lymph node surgery too?

For invasive cancer, the first lymph nodes in the armpit are usually checked with a sentinel node biopsy during the same operation. For DCIS alone this is not always needed. Your surgeon will explain what is planned for you.

Meet the Specialists

17+ senior cancer specialists. One panel for your case.

Trained at AIIMS, Tata Memorial, and leading international centres. Combined 150+ years of experience. Every complex case is reviewed by 3+ of them — together.

Dr. Naresh Gundu
Medical Oncologist

Dr. Naresh Gundu

MBBS, DNB (Internal Medicine), DM (Medical Oncology)

View Profile
Dr. C. Raghavendra Reddy
Medical Oncologist

Dr. C. Raghavendra Reddy

MBBS(Gold Medal), DNB(General Medicine), DM(Medical Oncology)(Gold Medal)

View Profile
Dr. Bharati Devi Gorantla
Medical Oncologist

Dr. Bharati Devi Gorantla

MBBS, MD(General Medicine), DM(Medical Oncology)(Adyar,Chennai), ECMO, MRCP SCE(UK)

View Profile
Dr. Owais Mohammed
Medical Oncologist

Dr. Owais Mohammed

MBBS, MD (General Medicine), DrNB (Medical Oncology), ECMO, MRCP SCE (Medical Oncology) (UK)

View Profile
Dr. T. Raghavender Reddy
Medical Oncologist

Dr. T. Raghavender Reddy

MBBS, DM (Medical Oncology), MD (Radiation Oncology)

View Profile
Dr. N. Kiranmayee
Medical Oncologist

Dr. N. Kiranmayee

MBBS, DM (Medical Oncology), MD (Internal Medicine)

View Profile
Dr. Muralidhar Muddusetty
Surgical Oncologist

Dr. Muralidhar Muddusetty

MBBS (AIIMS), MS (Surgery) (AIIMS), DNB (Surgical Oncology), MRCS (Edinburgh)

View Profile
Dr. Raghavendra Naik
Surgical Oncologist

Dr. Raghavendra Naik

MBBS, MS (General Surgery), M.Ch (Surgical Oncology)

View Profile
Dr. Mohammed  Imaduddin
Surgical Oncologist

Dr. Mohammed Imaduddin

M.B.B.S, MS (General Surgery), M.Ch (Surgical Oncology)

View Profile
Dr. Vinay Mamidala
Surgical Oncologist

Dr. Vinay Mamidala

MBBS, MS(General Surgery), M.Ch(Surgical Oncology), FMAS, FARIS(Ongoing)

View Profile
Dr. Paila Gowri Naidu
Surgical Oncologist

Dr. Paila Gowri Naidu

MBBS, MS (General Surgery), M.Ch (Surgical Oncology), FMAS

View Profile
Dr. Venkata Sushma P
Radiation Oncologist

Dr. Venkata Sushma P

MBBS, MD (Radiation Oncology)

View Profile
Dr. Kirti Ranjan Mohanty
Radiation Oncologist

Dr. Kirti Ranjan Mohanty

MBBS, MD (Radiation Oncology)

View Profile
Dr. Gangadhar Vajrala
Radiation Oncologist

Dr. Gangadhar Vajrala

MBBS, MD (Radiation Oncology), MPH

View Profile
Dr. Basudev Pokhrel
Hematologist

Dr. Basudev Pokhrel

MBBS, M.D (Immunohematology & Blood Transfusion)

View Profile
Dr. Vajja Sandeep Kumar
Surgical Oncologist

Dr. Vajja Sandeep Kumar

MBBS, MS (General Surgery), DrNB (Surgical Oncology), FALS Oncology

View Profile
Dr. Sridhar Kamani
Surgical Oncologist

Dr. Sridhar Kamani

MBBS, MS (General Surgery), DrNB (Surgical Oncology)

View Profile

Want a specific doctor for your case? Mention them when booking.

Book Free Consultation

Where to find us

Our centres in and around Hyderabad

Addressed by landmark, because that is how this city navigates. Each centre also names the areas it serves, so you can place it without a map. Consultation and day-care Chemotherapy run at every one of them.

CION Ameerpet

Beside Blue Fox Hotel, Satyam Theatre Road

Begumpet SR Nagar Punjagutta
CION Kukatpally

Opposite Big Bazaar, Mumbai Highway

KPHB JNTU Bharat Nagar
CION L.B. Nagar

Anu Arcade, next to L.B. Nagar Metro station

Vanasthalipuram Nagole Hayathnagar
CION Tolichowki

Inside Premier Hospital, Khader Bagh Road

Mehdipatnam Attapur Rethibowli
CION Masab Tank

Mahavir Hospital, AC Guards, Lakdikapul

Lakdikapul Khairatabad Basheer Bagh
CION Banjara Hills

Road No. 12

Jubilee Hills Madhapur Film Nagar
CION Kompally

Suchitra Circle, NH-44

Suchitra Circle Alwal Dundigal
CION Balanagar

Balanagar Main Road

Balanagar Fatehnagar Moosapet
CION Siddipet

Lohith Sai Hospital, Shivaji Nagar

Gajwel Husnabad Dubbaka
CION Sangareddy

X Roads, Pothreddipalle

Narayankhed Zaheerabad Patancheru

Talk to our team

Speak to a breast cancer specialist

Call the helpline or leave your details, and someone will help you arrange a consultation at the CION centre nearest you. One helpline serves every CION centre.

Call 1800 202 8726 Helpline open 24/7

Request a call back

Share your number and a specialist's team will call you.

Free call back. Your details stay private.

Sources

  1. American Cancer Society — Lumpectomy (breast-conserving surgery)
  2. Breast Cancer Now — Breast-conserving surgery
  3. RadiologyInfo — Breast needle localisation

This page is general information, not a prescription. Do not change or stop any treatment based on what you read here. If anything is worrying you, contact your own treating team — or call our helpline and we will help you reach the right specialist.

Call 1800 202 8726Book a consultation
Explore more

Breast Cancer Topics

Browse our complete guide to breast cancer — types, symptoms, tests and treatments. Tap any topic to read more.

HER2-Targeted Therapy

Cost of a full year of HER2 therapy in India De-escalated HER2 treatment for small tumours What happens if your heart function drops during treatment? Ejection fraction monitoring on HER2 therapy HER2-low breast cancer HER2-positive and hormone-positive together The full HER2 treatment pathway How does pertuzumab work, and who is it for? How does trastuzumab emtansine work, and who is it for? How long will you be on pertuzumab? Is adding pertuzumab worth the extra cost? Missed a dose of pertuzumab? What to do Missed a dose of trastuzumab emtansine? What to do Neratinib as extended adjuvant HER2 therapy Pertuzumab, fertility, menopause and sexual health How much does pertuzumab actually help? The numbers explained Pertuzumab cost in India Diarrhoea and rash on pertuzumab Heart function monitoring on dual HER2 blockade Pertuzumab infusion day Medicines, foods and supplements to avoid on pertuzumab Tests and monitoring while you are on pertuzumab Pertuzumab myths Pertuzumab (Perjeta) for breast cancer Pertuzumab side effects Pertuzumab T-DM1 infusion day Liver enzyme rises and nerve changes on T-DM1 Low platelets and bleeding risk on T-DM1 T-DM1 myths T-DM1 vs continuing trastuzumab after residual disease Trastuzumab emtansine (T-DM1) after residual disease Trastuzumab biosimilars in India Trastuzumab emtansine, fertility, menopause and sexual health How much does trastuzumab emtansine actually help? The numbers explained Trastuzumab emtansine cost in India Medicines, foods and supplements to avoid on trastuzumab emtansine Trastuzumab emtansine side effects Trastuzumab emtansine (Kadcyla) for breast cancer Lapatinib and tucatinib Why exactly twelve months of trastuzumab?

Hormone Therapy Medicines

Anastrozole, fertility, menopause and sexual health How much does anastrozole actually help? The numbers explained Anastrozole cost in India Medicines, foods and supplements to avoid on anastrozole Cholesterol, bone density and long-term effects of anastrozole Tests and monitoring while you are on anastrozole Anastrozole myths Anastrozole side effects Anastrozole vs tamoxifen Anastrozole (Arimidex) for breast cancer Exemestane, fertility, menopause and sexual health How much does exemestane actually help? The numbers explained Exemestane cost in India Medicines, foods and supplements to avoid on exemestane Joint pain and fatigue on exemestane Tests and monitoring while you are on exemestane Exemestane myths Exemestane side effects Why exemestane is taken after food and its steroidal effects Exemestane (Aromasin) for breast cancer Fulvestrant, fertility, menopause and sexual health How much does fulvestrant actually help? The numbers explained Fulvestrant cost in India Injection site pain and reactions on fulvestrant The fulvestrant injection Medicines, foods and supplements to avoid on fulvestrant Tests and monitoring while you are on fulvestrant Fulvestrant myths Fulvestrant side effects Fulvestrant vs aromatase inhibitors in advanced disease Fulvestrant (Faslodex) for breast cancer How much does goserelin actually help? The numbers explained Bone loss and mood changes on ovarian suppression Goserelin cost in India The goserelin implant Medicines, foods and supplements to avoid on goserelin Sudden menopause symptoms from ovarian suppression Tests and monitoring while you are on goserelin Goserelin myths Goserelin side effects Goserelin injections vs surgical ovary removal Goserelin (Zoladex) for breast cancer Hot flushes, joint pain and fatigue on fulvestrant How does anastrozole work, and who is it for? How does exemestane work, and who is it for? How does fulvestrant work, and who is it for? How does goserelin work, and who is it for? How does letrozole work, and who is it for? Postmenopausal hormone-receptor-positive breast cancer How long will you be on anastrozole? How long will you be on exemestane? How long will you be on fulvestrant? How long will you be on goserelin? How long will you be on letrozole? Taking anastrozole Taking exemestane Taking letrozole Letrozole, fertility, menopause and sexual health How much does letrozole actually help? The numbers explained Bone thinning on letrozole Letrozole cost in India Medicines, foods and supplements to avoid on letrozole Joint pain and morning stiffness on letrozole Tests and monitoring while you are on letrozole Letrozole myths Letrozole side effects Letrozole vs anastrozole vs exemestane Letrozole (Femara) for breast cancer Missed a dose of anastrozole? What to do Missed a dose of exemestane? What to do Missed a dose of fulvestrant? What to do Missed a dose of goserelin? What to do Missed a dose of letrozole? What to do Exemestane after letrozole or anastrozole Will your periods and fertility return after stopping goserelin?

Targeted & Newer Medicines

Abemaciclib, fertility, menopause and sexual health How much does abemaciclib actually help? The numbers explained Abemaciclib cost in India Diarrhoea on abemaciclib Two years of abemaciclib after surgery Medicines, foods and supplements to avoid on abemaciclib Tests and monitoring while you are on abemaciclib Abemaciclib myths Abemaciclib side effects Abemaciclib vs other CDK4/6 inhibitors Abemaciclib (Verzenio) for breast cancer CDK4/6 inhibitors in early breast cancer after surgery Adjuvant olaparib after surgery for BRCA carriers Alpelisib, fertility, menopause and sexual health How much does alpelisib actually help? The numbers explained Alpelisib cost in India High blood sugar on alpelisib Medicines, foods and supplements to avoid on alpelisib Tests and monitoring while you are on alpelisib Alpelisib myths Alpelisib (Piqray) for breast cancer Rash and mouth sores on alpelisib Alpelisib side effects Alpelisib vs everolimus after endocrine therapy fails Alpelisib for PIK3CA-mutated breast cancer CDK4/6 inhibitors in breast cancer Everolimus in hormone-resistant breast cancer How does abemaciclib work, and who is it for? How does ribociclib work, and who is it for? How does sacituzumab govitecan work, and who is it for? How long will you be on alpelisib? How long will you be on ribociclib? How long will you be on sacituzumab govitecan? Taking abemaciclib Taking alpelisib Taking ribociclib Liquid biopsy in metastatic breast cancer Missed a dose of abemaciclib? What to do Missed a dose of alpelisib? What to do Missed a dose of ribociclib? What to do Missed a dose of sacituzumab govitecan? What to do Newer drugs Elacestrant and oral SERDs for ESR1-mutant disease PARP inhibitors for BRCA-mutated breast cancer Do you need a PIK3CA test before alpelisib? Ribociclib, fertility, menopause and sexual health How much does ribociclib actually help? The numbers explained Ribociclib cost in India ECG monitoring and QT prolongation on ribociclib Medicines, foods and supplements to avoid on ribociclib Low white cell counts on ribociclib Tests and monitoring while you are on ribociclib Ribociclib myths Ribociclib side effects Ribociclib (Kisqali) for breast cancer Sacituzumab govitecan, fertility, menopause and sexual health How much does sacituzumab govitecan actually help? The numbers explained Sacituzumab govitecan cost and availability in India Diarrhoea on sacituzumab govitecan and how it is managed Medicines, foods and supplements to avoid on sacituzumab govitecan Tests and monitoring while you are on sacituzumab govitecan Sacituzumab govitecan myths Low counts, fever risk and hair loss on sacituzumab govitecan Sacituzumab govitecan infusion days Sacituzumab govitecan side effects Sacituzumab govitecan for triple-negative breast cancer Sacituzumab govitecan vs standard chemotherapy in triple negative breast cancer How newer drugs are sequenced with older ones

Metastatic Breast Cancer

What comes after a CDK4/6 inhibitor stops working? Ascites and abdominal swelling in advanced breast cancer Is my back pain bone metastasis or something else? Bone marrow involvement in advanced breast cancer Bone metastases in breast cancer Brain metastases in breast cancer Tumour markers CA 15-3 and CEA in metastatic breast cancer Chest wall and local recurrence after mastectomy Clinical trials in metastatic breast cancer Cost of long-term metastatic breast cancer treatment in India Explaining metastatic breast cancer to family and friends First-line treatment for hormone-positive metastatic breast cancer Confusion, thirst and drowsiness Lines of treatment in metastatic breast cancer Liver metastases in breast cancer Living well with metastatic breast cancer for years Lung metastases and pleural effusion in breast cancer Malignant pleural effusion Metastatic breast cancer and pink-ribbon culture Prognosis in metastatic breast cancer Treatment sequence in metastatic HER2-positive breast cancer Treatment options in metastatic triple negative breast cancer Oligometastatic breast cancer Why receptors are re-tested on a metastatic biopsy Scan intervals and monitoring in metastatic disease Understanding scan reports in metastatic breast cancer Skin metastases and nodules on the chest Surgery and radiation in metastatic breast cancer Treatment holidays and breaks in metastatic breast cancer When do doctors switch treatment in metastatic disease? Where breast cancer spreads and what each site feels like Working and earning with metastatic breast cancer
Call now Book free consultation