CION Cancer Clinics
Kidney, ovarian and sarcoma cancer that has spread to the liver | CION Cancer Clinics
When kidney cancer, ovarian cancer or a sarcoma spreads to the liver, it is still that original cancer and is treated with its own medicines. It is not the same as cancer that starts in the liver. This page explains how each of these three cancers behaves in the liver, what usually happens after the scan, and when surgery or other liver treatment is discussed. At CION Cancer Clinics, a multidisciplinary tumour board weighs your liver function and your scans before recommending any treatment.
On this page
- What does it mean when kidney, ovarian or sarcoma cancer reaches the liver?
- How does each of these cancers behave in the liver?
- What usually happens once liver spots are found?
- Which treatments are used for each of these cancers?
- What do the words on the scan report mean?
- What this page cannot tell you
- Common questions about kidney, ovarian and sarcoma spread to the liver
The short answer
What does it mean when kidney, ovarian or sarcoma cancer reaches the liver?
It means cancer that started in the kidney, the ovary or a sarcoma has formed new spots in the liver. This is secondary liver cancer. It is treated as the original cancer, with the medicines and plans that suit that cancer, not as a cancer of the liver itself.
So a kidney cancer spot in the liver is still kidney cancer under the microscope. An ovarian cancer deposit is still ovarian cancer. That one fact decides almost everything that follows, from the medicines offered to whether surgery is even discussed.
Why these three are grouped on one page
These cancers reach the liver less often than bowel, breast, lung or pancreatic cancer. When they do, each behaves in its own way, and each has its own treatment path. This page gives you the general shape of each one and then points you to the pages that go deeper. If your report talks about spread from the bowel, read our page on colorectal cancer that has reached the liver instead.
If you have not been told where the cancer started, that question has to be answered first. Treatment cannot be planned without it.Three different patterns
How does each of these cancers behave in the liver?
The word metastasis sounds the same for all three. The plans behind it are quite different.
Kidney cancer
The most common type, renal cell carcinoma, can spread through the blood to the liver, lungs, bones or brain. It does not usually respond well to standard chemotherapy. Treatment is built around immunotherapy and targeted tablets instead. Read more about metastatic kidney cancer.
Ovarian cancer
Ovarian cancer usually spreads inside the abdomen first. Deposits often sit on the surface of the liver, on its outer lining, rather than deep inside it. The two are staged differently and treated differently.
What the team asks
- Is the spot on the surface or inside the liver?
- Can it be removed during the main abdominal operation?
- Is there a BRCA or similar gene result?
Sarcoma
Sarcomas are cancers of muscle, fat, bone and other connective tissue. Some types, such as gastrointestinal stromal tumour (GIST) and leiomyosarcoma, spread to the liver more than others. GIST is treated very differently from other sarcomas because it responds to targeted tablets.
What they share
In all three, medicine through the bloodstream usually comes first. Surgery or another liver-directed treatment is considered only in carefully chosen people with a small number of spots.
Not sure whether this applies to you?
Ask an oncologistAfter the scan
What usually happens once liver spots are found?
Confirming what the spots are
The scan raises the question. A biopsy, a sample of tissue taken with a fine needle, often answers it. It confirms that the spot is the same cancer and not a new, different one. CION arranges the biopsy and scans through partner hospitals and diagnostic centres.
Mapping the rest of the body
A CT, MRI or PET-CT scan shows whether the liver is the only place involved. Spread to the lungs, bones or abdominal lining changes the plan.
The tumour board review
Medical, surgical and radiation oncologists review the scans and the pathology together. They weigh the type of cancer, how many liver spots there are, how the liver is working and how well you are.
A written plan
Most people start with medicine through the bloodstream. If the spots shrink or stay still, the team may then discuss liver-directed treatment such as surgery or ablation.
Treatment, in outline
Which treatments are used for each of these cancers?
For kidney cancer, the main tools are immunotherapy drugs such as nivolumab or pembrolizumab, and targeted tablets such as cabozantinib or sunitinib, often in combination. In a few people with one or two liver spots that stay stable, removing them may be discussed. Several of these medicines are available in India. Your oncologist will tell you which ones suit you and how they are funded.
For ovarian cancer, platinum-based chemotherapy is the usual backbone. Surface deposits on the liver can sometimes be removed during the main surgery to clear the abdomen. People with a BRCA fault may be offered a PARP inhibitor tablet afterwards to hold the cancer back.
For GIST, imatinib, a targeted tablet, is the first treatment and is widely available in India. Other sarcomas are treated with chemotherapy, and selected people with a few liver spots may be offered surgery or ablation. Read the metastatic sarcoma treatment page for the detail.
Drug names are given so you recognise them. Doses and schedules are decided only by your oncologist.Leave a number, we will call you
One field. No form to fill in, and no charge for the call.
On your report
What do the words on the scan report mean?
- Hepatic metastases
- Cancer spots in the liver that started somewhere else. Hepatic simply means of the liver.
- Capsular or surface deposit
- A spot sitting on the outer lining of the liver. Common in ovarian cancer, and often removable with the abdominal operation.
- Parenchymal metastasis
- A spot inside the substance of the liver itself, rather than on its surface.
- Oligometastatic
- Only a few spots of spread. This is the group in which surgery or ablation is most often discussed.
- Renal cell carcinoma
- The most common type of kidney cancer in adults.
- GIST
- Gastrointestinal stromal tumour, a sarcoma that usually starts in the stomach or small bowel and responds to targeted tablets.
A liver spot found many years after kidney cancer surgery can still be kidney cancer. This cancer is known for returning late, which is why follow-up scans continue long after the operation.
Being straight with you
What this page cannot tell you
It cannot tell you whether the spot on your scan is cancer, or how your own illness will go. That depends on the type of cancer, the number and position of the liver spots, what else the scan shows and how you respond to the first treatment. Only the team that has seen your scans and pathology can answer it.
Who this page does not apply to
If the cancer started in the liver itself, called hepatocellular carcinoma, this page is not for you. Read about primary and secondary liver cancer first. It also does not cover bowel, breast, lung, stomach or pancreatic cancer that has spread to the liver. Each of those has its own page.
When the evidence is thin
Because these spreads are less common, there are fewer large studies of liver surgery or ablation for them. Decisions lean more on the tumour board's judgement. Asking for a second opinion on such a decision is reasonable, and no good team minds it.
Questions we are asked
Common questions about kidney, ovarian and sarcoma spread to the liver
Is this the same as liver cancer?
No. Doctors call it secondary liver cancer, but the cells are kidney, ovarian or sarcoma cells. It is treated with the medicines for the original cancer. Treatments designed for cancer that starts in the liver are usually not the right choice here.
Can the liver spots be removed by surgery?
Sometimes. Surgery is considered when there are only a few spots, the rest of the cancer is controlled and you are fit enough. CION's surgical oncologists assess this with the tumour board. Your team will tell you where the operation takes place.
Does chemotherapy work for kidney cancer in the liver?
Standard chemotherapy usually does little for the common type of kidney cancer. Immunotherapy and targeted tablets are used instead, often together. Your oncologist will explain which combination suits you and how it will be checked with scans.
My mother's ovarian cancer has spots on the liver. Is it stage four?
It depends where the spots sit. Deposits on the surface of the liver are often counted as abdominal spread, not stage four. Spots inside the liver tissue usually are stage four. Ask the team which one the report describes, as it changes the surgical plan.
Why is GIST treated differently from other sarcomas?
Most GISTs are driven by a gene change that targeted tablets such as imatinib can block. Other sarcomas do not have this target. A mutation test on the tumour tissue helps the team choose the right tablet and judge how well it may work.
Do I need a biopsy of the liver spot?
Often, yes, especially if the original cancer was treated long ago or the scan pattern is unusual. A biopsy confirms the type and can guide treatment. Read what happens during a liver biopsy.
Will the liver stop working?
Usually not, at least not early on. The liver has a large reserve and keeps working even with several spots. Blood tests check this throughout treatment. Yellow eyes, a swollen tummy or new confusion should be reported to the team straight away.
Where do we start if we have just been told?
Gather every scan, report and old surgery paper, including the original pathology. Bring them to a medical oncologist for review. Call the CION helpline if you are unsure who to see, and someone will help you arrange the appointment.
Meet CION's liver cancer specialists. Bring your scan reports and liver blood tests.
Our medical and surgical oncologists plan liver cancer care together, weighing the tumour and how well your liver works before choosing surgery, a liver-directed procedure or medicines.
Dr. C. Raghavendra Reddy
MBBS(Gold Medal), DNB(General Medicine), DM(Medical Oncology)(Gold Medal)
Dr. Bharati Devi Gorantla
MBBS, MD(General Medicine), DM(Medical Oncology)(Adyar,Chennai), ECMO, MRCP SCE(UK)
Dr. Owais Mohammed
MBBS, MD (General Medicine), DrNB (Medical Oncology), ECMO, MRCP SCE (Medical Oncology) (UK)
Dr. Muralidhar Muddusetty
MBBS (AIIMS), MS (Surgery) (AIIMS), DNB (Surgical Oncology), MRCS (Edinburgh)
Want a specific doctor for your case? Mention them when booking.
Book Free ConsultationBook an appointment with our specialist
Share your name and number — we'll call you back within 30 minutes to schedule your consultation.
Sources
- Cancer Research UK — Secondary liver cancer
- National Cancer Institute — Metastatic Cancer: When Cancer Spreads
- Macmillan Cancer Support — Secondary cancer
- National Cancer Institute — Targeted Therapy for Cancer
This page is general information, not a prescription. Do not change or stop any treatment based on what you read here. If anything is worrying you, contact your own treating team — or call our helpline and we will help you reach the right specialist.
Keep reading
Related pages
Talk to us
Has a scan found spots in the liver after another cancer?
Send us the scans and old reports, and a medical oncologist will review what the spread means for the plan. One helpline serves every CION centre.