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What cirrhosis is, and why it matters for liver cancer | CION Cancer Clinics
Cirrhosis is scarring that has spread through the whole liver after years of injury from a virus, fat, alcohol or the immune system. A scarred liver can keep working for a long time, so many people feel well. It is not cancer, but it raises the risk of primary liver cancer and limits how that cancer can be treated. This page explains what it is and how it is found. At CION Cancer Clinics, our specialists help you understand your own risk and plan regular liver checks that fit it.
The short answer
What is cirrhosis of the liver, in plain words?
Cirrhosis is scarring of the liver that has spread through the whole organ. Years of injury, from a virus, fat, alcohol or the body's own immune system, leave scar tissue behind, and the scars slowly replace healthy liver.
A scarred liver is harder, lumpier and works less well. Blood finds it harder to flow through, and the liver cells that are left have to do the work of the ones that were lost. Many people feel completely well for a long time, which is why cirrhosis is so often found by accident on a scan done for something else.
Why a cancer team talks about it
Cirrhosis is the soil in which most primary liver cancer grows. It is also the limit on treatment. A doctor planning surgery or a procedure for a liver tumour has to ask how much healthy liver will be left, and in cirrhosis the answer is often not enough. No other cancer depends so much on the organ around it.
This page is about the liver's own scarring. If you were told cancer has spread to the liver from the bowel, breast or elsewhere, that is a different situation, explained on the two very different things called liver cancer.
Cirrhosis is a diagnosis about the liver. It is not a cancer diagnosis.What scarring does
What does a scarred liver stop doing well?
The liver has several jobs at once. Cirrhosis affects each of them, usually slowly.
Letting blood through
Scar tissue squeezes the veins inside the liver. Pressure builds in the portal vein, the large vein that carries blood from the gut to the liver. Doctors call this portal hypertension.
It can lead to
- Swollen veins in the food pipe, called varices
- Fluid in the abdomen, called ascites
- A large spleen and a low platelet count
Making proteins
The liver makes albumin, which keeps fluid inside the blood vessels, and the clotting proteins that stop bleeding. When these fall, ankles swell and bruises come easily.
Clearing waste
A healthy liver clears bilirubin, the yellow pigment from old blood cells, and toxins made in the gut. When it cannot keep up, the eyes turn yellow, or the brain slows and a person becomes confused or drowsy. That confusion is called hepatic encephalopathy.
Renewing itself safely
The liver repairs itself by making new cells. In a scarred liver that constant repair can go wrong, and one small group of cells can turn into a tumour. This is why people with cirrhosis are offered regular cancer checks.
Not sure whether this applies to you?
Ask an oncologistHow it builds up
How does a healthy liver become a cirrhotic one?
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An injury that keeps going
Hepatitis B or C, fat building up inside liver cells, regular alcohol, an immune attack or a stored metal such as iron or copper keeps damaging liver cells. One injury heals. A constant one does not.
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Inflammation and early scarring
Each round of damage leaves a little scar tissue, called fibrosis. At this point the liver still works normally and most people feel nothing. Early fibrosis can often settle if the cause is removed.
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Scars join up
Over years, bands of scar link together and divide the liver into small islands of surviving tissue, called nodules. When this pattern runs through the whole liver, it is called cirrhosis.
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Compensated cirrhosis
The liver is scarred but still coping. Blood tests may be nearly normal. Many people stay at this stage for a long time, especially once the cause is treated. You can read how this differs from the next stage on compensated versus decompensated cirrhosis.
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Decompensated cirrhosis
The liver can no longer keep up. Fluid gathers, jaundice appears, varices bleed or confusion sets in. This stage needs close hepatology care and shapes every treatment decision that follows.
Finding it
How do doctors know it is cirrhosis?
An ultrasound or a blood test raises the question
The report may say "coarse echotexture", "nodular surface" or "features of chronic liver disease". A low platelet count on a routine test is another common clue.
Liver stiffness is measured
A FibroScan, a quick ultrasound-based test, measures how stiff the liver is. Stiffer usually means more scar. The numbers are explained on FibroScan and liver stiffness.
The cause is searched for
Blood tests check for hepatitis B and C, iron and copper overload and immune markers. Questions about alcohol, diabetes and weight are routine and asked of everyone.
Function is scored
Bilirubin, albumin, the INR clotting test and any fluid or confusion are combined into a Child-Pugh or MELD score. These describe how well the liver is coping, not how scarred it looks.
Sometimes, a biopsy
When the picture is unclear, a small sample of liver may be taken. CION arranges scans and biopsy through accredited diagnostic partners.
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On your report
What do the words on a cirrhosis report mean?
- Fibrosis
- Scar tissue in the liver. It is graded in stages, and the last stage is cirrhosis.
- Chronic liver disease (CLD)
- Long-standing liver damage of any cause. Cirrhosis is its most advanced form.
- Portal hypertension
- High pressure in the vein that carries blood from the gut into the liver, caused by scarring.
- Ascites
- Fluid collecting in the abdomen, which makes the belly swell.
- Varices
- Swollen veins, usually in the food pipe or stomach, that can bleed.
- Splenomegaly
- An enlarged spleen. It often goes with portal hypertension and a low platelet count.
People with cirrhosis are usually advised to have a liver ultrasound, often with an AFP blood test, every six months, even when they feel well. Small tumours found this way are far more often curable than tumours found because of symptoms.
Being straight with you
What this page cannot tell you
It cannot tell you whether you have cirrhosis, or how advanced it is. An ultrasound phrase on its own is not a diagnosis. That needs a hepatologist or physician who puts your scans, stiffness reading and blood tests together.
It cannot tell you what your future looks like
Two people with cirrhosis can have very different courses. Much depends on whether the cause can be treated, whether the liver is still coping, and whether surveillance is kept up. Your own doctor is the only person who can talk about your outlook.
Who this does not apply to
If your scan says only "fatty liver" or "mild fibrosis", you do not have cirrhosis, and most people with those findings never develop it. Start with what fatty liver actually is instead.
Vomiting blood, black stools, new confusion or fever with a swollen belly needs hospital today. Do not wait for an appointment.Questions we are asked
Common questions about cirrhosis
Is cirrhosis the same as liver cancer?
No. Cirrhosis is scarring, and most people with cirrhosis do not have cancer. It does raise the risk of a primary liver cancer called hepatocellular carcinoma (HCC), which is why regular surveillance scans are advised. If a scan shows a lump, a specialist team decides what it is.
Can cirrhosis be reversed?
Some scarring can soften when the cause is removed, for example after hepatitis C treatment or stopping alcohol. Established cirrhosis rarely disappears completely, but the liver often stops getting worse. The detail is on can cirrhosis be reversed.
Does cirrhosis always come from drinking?
No. In India, hepatitis B, hepatitis C and fatty liver linked to diabetes and weight are major causes, alongside alcohol and rarer immune or inherited conditions. Many people with cirrhosis have never drunk alcohol at all. The diagnosis says nothing about what kind of person you are.
What symptoms does cirrhosis cause?
Early on, often none. Later there may be tiredness, poor appetite, itching, easy bruising, swollen ankles, a swollen belly or yellow eyes. Vomiting blood, black stools or new confusion are emergencies and need hospital the same day.
Should someone with cirrhosis cut down on protein?
Usually not. Many families cut dal, eggs and meat thinking it protects the liver, but people with cirrhosis lose muscle quickly and generally need enough protein. Ask your doctor or dietitian before restricting anything, and avoid herbal liver tonics unless your doctor has agreed.
Can a person with cirrhosis have cancer treatment?
Often yes, but the options depend on how well the liver is coping as much as on the tumour. A team weighs surgery, procedures such as TACE or ablation, and medicines against the liver's reserve. CION's tumour board reviews each case and coordinates procedures through partner hospitals.
Do family members need to be checked?
If the cause is hepatitis B, household members should be tested and vaccinated if not protected. Inherited causes such as haemochromatosis or Wilson's disease also call for family testing. For other causes, ask your doctor whether relatives share the same risk factors.
Who should I see about cirrhosis?
A hepatologist or gastroenterologist manages the cirrhosis itself. If a scan has shown a lump in the liver, an oncology team should be involved too. Call the CION helpline if you are not sure where to start, and someone will guide you to the right clinic.
Meet CION's liver cancer specialists. Bring your scan reports and liver blood tests.
Our medical and surgical oncologists plan liver cancer care together, weighing the tumour and how well your liver works before choosing surgery, a liver-directed procedure or medicines.
Dr. C. Raghavendra Reddy
MBBS(Gold Medal), DNB(General Medicine), DM(Medical Oncology)(Gold Medal)
Dr. Bharati Devi Gorantla
MBBS, MD(General Medicine), DM(Medical Oncology)(Adyar,Chennai), ECMO, MRCP SCE(UK)
Dr. Owais Mohammed
MBBS, MD (General Medicine), DrNB (Medical Oncology), ECMO, MRCP SCE (Medical Oncology) (UK)
Dr. Muralidhar Muddusetty
MBBS (AIIMS), MS (Surgery) (AIIMS), DNB (Surgical Oncology), MRCS (Edinburgh)
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Sources
- NIDDK — Cirrhosis - NIDDK
- NHS — Cirrhosis
- Liver UK (formerly British Liver Trust) — Cirrhosis
- Merck Manual Consumer Version — Cirrhosis of the Liver
This page is general information, not a prescription. Do not change or stop any treatment based on what you read here. If anything is worrying you, contact your own treating team — or call our helpline and we will help you reach the right specialist.
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